Protein DOCK1 map

Identifiers
dedicator of cytokinesis 1
"dedicator of cyto-kinesis 1"
HUGO:DOCK1 HGNC:2987 ENTREZ:1793 UNIPROT:Q14185
HUGO:DOC1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:15308668
DOCK1 (so-called DOCK180) is a GEF of Rac1.
DOCK1 together with paxillin-Crk constitutes the main pathway transducing collagen-mediated signals for the activation of Rac1.
This signaling pathway is down-regulated when cell migration is counteracted by C3G/Rap1 activation.
A balance between Rac1 and Rap1 GTPases in controlling the migratory versus the stationary state of the cell is suggested.
PMID:12432077
DOCK1 is a GEF for Rac1 and possibly for CDC42
PMID:9808620
DOCK1 is involved in integrin signaling through Crk-p130Cas complexes.
DOCK1 activates JNK in a Rac1, Cdc42 - dependent manner
Overexpression of DOCK1 increases the amount of GTP-bound Rac1
Coexpression of Crk2 and p130Cas (BCAR1) enhances this DOCK1-dependent activation of Rac1.
Direct binding of DOCK1 to Rac1, but not to RhoA or Cdc42.
To sum up, DOCK1 is a novel activator of Rac1 and involved in integrin signaling.
 DENDRITIC_CELL  map
CASCADE:INTEGRIN_AVB5
PMID:14697347, PMID:11146654
Integrin ??v??5 regulates phagocytosis via CRK /DOCK1 (DOCK180) /RAC1 pathway downstream of.
Integrin ??v??5 activation results in recruitment of the p130cas???CrkII???Dock180 complex and RAC1 activation.

DOCK1@Cytosol

References
em_emtc_emtc_re982( EMT Senescence  map ):
PMID:15308668
DOCK1 (so-called DOCK180) is a GEF of Rac1.
DOCK1 together with paxillin-Crk constitutes the main pathway transducing collagen-mediated signals for the activation of Rac1.
This signaling pathway is down-regulated when cell migration is counteracted by C3G/Rap1 activation.
A balance between Rac1 and Rap1 GTPases in controlling the migratory versus the stationary state of the cell is suggested.
PMID:12432077
DOCK1 is a GEF for Rac1 and possibly for CDC42
PMID:9808620
DOCK1 is involved in integrin signaling through Crk-p130Cas complexes.
DOCK1 activates JNK in a Rac1, Cdc42 - dependent manner
Overexpression of DOCK1 increases the amount of GTP-bound Rac1
Coexpression of Crk2 and p130Cas (BCAR1) enhances this DOCK1-dependent activation of Rac1.
Direct binding of DOCK1 to Rac1, but not to RhoA or Cdc42.
To sum up, DOCK1 is a novel activator of Rac1 and involved in integrin signaling.
em_emtc_emtc_re981( EMT Senescence  map ):
PMID:16000375
Src and FAK kinases cooperate to phosphorylate paxillin, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Phosphorylated paxillin binding to Crk is implicated in Rac activation and stimulation of cell motility
CRK bound to DOCK1 (so-called DOCK180) forms complex with phosphorylated paxillin.
The complex is necessary for collagen-dependent cell migration, mainly through Rac1 activation.

Modifications:
In compartment: Cytosol
  1. DOCK1@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. DOCK1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. DOCK1:​PXN|​pho@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PXN|​pho@Cytosol map + CRK@Cytosol map + DOCK1@Cytosol map → map DOCK1:​PXN|​pho@Cytosol map
  2. Rac1_GEFs*@Cytosol map → map DOCK1@Cytosol map
  3. DOCK1:​PXN|​pho@Cytosol map → map Membrane spreading@Cytosol map
  4. CRK@INNATE_IMMUNE_CELL_Cytosol map + DOCK1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. GDP:​RAC1_2*@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAC1_2*)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map