Protein Actinin* map

Identifiers
Actinin*
actinin, alpha 1
HUGO:ACTN1 HGNC:163 ENTREZ:87 UNIPROT:P12814
actinin, alpha 2
HUGO:ACTN2 HGNC:164 ENTREZ:88 UNIPROT:P35609
actinin, alpha 4
"focal segmental glomerulosclerosis 1", FSGS1
HUGO:ACTN4 HGNC:166 ENTREZ:81 UNIPROT:O43707

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:15688067
Alpha-actinin is a cytoskeletal protein that binds to viculin (VCL).
Via this binding, Alpha-actinin crosslinks actin (in actomyosin stress fibres) and tether them to the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) reduces the crossliking of stress fibres and prevents the maturation of focal contacts.

Actinin*@Cytosol

References
em_emtc_emtc_re987( EMT Senescence  map ):
PMID:15688067
Alpha-actinin servers a link between cytoskeletal actin (in stress fibres) and vinculin at the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) redues this ability of linking actin to vinculin, thus prevents the maturation of focal contacts.
em_emtc_emtc_re991( EMT Senescence  map ):
Alpha-actinin is a cytoskeletal protein that binds to viculin (VCL).
Via this binding, Alpha-actinin crosslinks actin (in actomyosin stress fibres) and tether them to the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) reduces the crossliking of stress fibres and prevents the maturation of focal contacts.

Actinin*|​pho@Cytosol

References
em_emtc_emtc_re991( EMT Senescence  map ):
PMID:15688067
Alpha-actinin is a cytoskeletal protein that binds to viculin (VCL).
Via this binding, Alpha-actinin crosslinks actin (in actomyosin stress fibres) and tether them to the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) reduces the crossliking of stress fibres and prevents the maturation of focal contacts.

Modifications:
In compartment: Cytosol
  1. Actinin*@Cytosol map
  2. Actinin*|​pho@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  2. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​ZYX:​c-SRC*@Cytosol map
  3. ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Actinin*@Cytosol map → map ACTN1@Cytosol map
  2. Actinin*@Cytosol map → map ACTN2@Cytosol map
  3. Actinin*@Cytosol map → map ACTN4@Cytosol map
  4. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map + Actinin*@Cytosol map + Actin cytoskeletal*@Cytosol map → map Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  5. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map + ZYX@Cytosol map → map Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​ZYX:​c-SRC*@Cytosol map
  6. ARP2_3*@Cytosol map + Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map → map ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  7. ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map → map Actin polymerization@Nucleus map
  8. Actinin*@Cytosol map → map Actinin*|​pho@Cytosol map
As Catalyser: