Identifiers
ARP2/3*
ARP2 actin-related protein 2 homolog (yeast)
"ARP2 (actin-related protein 2, yeast) homolog"
HUGO:ACTR2 HGNC:169 ENTREZ:10097 UNIPROT:P61160
ARP3 actin-related protein 3 homolog (yeast)
"ARP3 (actin-related protein 3, yeast) homolog"
HUGO:ACTR3 HGNC:170 ENTREZ:10096 UNIPROT:P61158
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
em_emtc_emtc_re791( EMT Senescence ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:14749719
PAK1 phosphorylates and activates ARP2_3 complex.
em_emtc_emtc_re798( EMT Senescence ):
PMID:15094799
ARP2_3 complex nucleates new actin filaments from the sides of preexisting filaments.
→ ACTR2@Cytosol
→ ACTR3@Cytosol
→ ARP2_3*@Cytosol
+ ARP2_3*@Cytosol → em_emtc_emtc_s2991
+ Actinin*:BCAR1:FAK1*|Y_pho|pho:PXN|pho:Talin*:c-SRC*@Cytosol → ARP2_3*:Actinin*:BCAR1:FAK1*|Y_pho|pho:PXN|pho:Talin*:c-SRC*@Cytosol
→ Actin polymerization@Nucleus