Phenotype Actin polymerization map
Actin polymerization@T_cell

References
PMID:14612578 PMID:16887996 PMID:26552706

Actin polymerization@Nucleus

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
em_emtc_emtc_re715( EMT Senescence  map ):
PMID:9265657
ERM proteins can reconstitute stress fiber assembly, cortical actin polymerization and focal complex formation in response to activation of Rho and Rac
em_emtc_emtc_re799( EMT Senescence  map ):
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
em_emtc_emtc_re852( EMT Senescence  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
em_emtc_emtc_re899( EMT Senescence  map ):
PMID:15866889
The ARP2_3 complex and Cofilin are involved in protrusion at the leading edge: the actin-severing activity of cofilin and the actin-branching activity of Arp2_3 act in synergy to drive the extension of lamellipodia.
Cofilin is also required for the maintenance of a polarized cytoskeleton and thus for directional cell migration.
Integrins control motile strategy through a Rho-cofilin pathway.
Adhesion to fibronectin by a5b1 integrin leads to phosphorylation and thus inactivation of cofilin.
Cells thus fail to polarize their cytoskeleton but extend thin protrusion with cell-matrix adhesions in multiple directions.

Actin polymerization@INNATE_IMMUNE_CELL_Cytosol

References
 DENDRITIC_CELL  map
in_re28( Innate Immunity  map ):
PMID:21458045
MHC-II transport was controlled by the GTPase ARL14/ARF7, which recruits the motor myosin 1E via an EFFECTOR_ACTIVATION protein ARF7EP. This complex controls movement of MHC-II vesicles along the actin cytoskeleton in human dendritic cells (DCs).

Modifications:
In compartment: Cytosol
  1. Actin polymerization@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Actin polymerization@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. Actin polymerization@Nucleus map
In compartment: T_cell
  1. Actin polymerization@T_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Actin polymerization@T_cell map → map Granules exocytosis@default map
    2. Actin cytoskeletal*|​hm2@T_cell map → map Actin polymerization@T_cell map
    3. Actin polymerization@Cytosol map → map Actomyosin_contractility@default map
    4. Actin cytoskeletal*|​hm2|​active@Cytosol map → map Actin polymerization@Cytosol map
    5. Actin polymerization@Cytosol map → map Stress_fibrilles_formation@Cytosol map
    6. ERM*|​open@Cytosol map → map Actin polymerization@Nucleus map
    7. em_emtc_emtc_s2958 → map Actin polymerization@Nucleus map
    8. RHOB:​RhoB_cytoskeletal_effectors*@Cytosol map → map Actin polymerization@Nucleus map
    9. Actin polymerization@Nucleus map → map Cytoskeleton remodeling@Nucleus map
    10. em_emtc_emtc_s2991 → map Actin polymerization@Nucleus map
    11. em_emtc_emtc_s2995 → map Actin polymerization@Nucleus map
    12. em_emtc_emtc_s3022 → map Actin polymerization@Nucleus map
    13. em_emtc_emtc_s3056 → map Actin polymerization@Nucleus map
    14. ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map → map Actin polymerization@Nucleus map
    15. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin polymerization@INNATE_IMMUNE_CELL_Cytosol map
    16. RHOA:​ROCK*@Cytoplasm map → map Actin polymerization@Nucleus map
    As Catalyser:
    1. MHC_class_II*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map MHC_class_II*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map