Protein TNF map

Identifiers
HUGO:TNF

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:21133840
TNF is a pleiotropic cytokine produced by many different types of cells in the body. However, cells of the monocytic lineage???such as macrophages, astroglia, microglia, Langerhans cells, Kupffer cells, and alveolar macrophages???are the primary synthesizers of TNF
PMID:1431106
TNF induced tumoricidal activity of macrophages.
PMID:14607933,??PMID:14625680
TNF and IFNG cooperate in the activation of macrophages.

TNF@Cytosol

Identifiers

Maps_Modules

References

TNF@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. TNF@Cytosol map
In compartment: default
  1. TNF@default map
Participates in complexes:
In compartment: Membrane
  1. TNF:​TNFR2*:​TRAF1:​TRAF2@Membrane map
  2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map
  3. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
Participates in reactions:
As Reactant or Product:
  1. rTNF@Cytosol map → map TNF@Cytosol map
  2. TNF@Cytosol map → map TNF@default map
  3. TNF@default map → map Angiogenesis@default map
  4. TNF@default map + TNFR1*@Membrane map + TRADD@Cytosol map + TRAF2@Cytosol map + RIPK1@Cytosol map + FADD@Cytosol map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map
  5. TNF@default map + TNFR2*@Membrane map + TRAF1@Cytosol map + TRAF2@Cytosol map → map TNF:​TNFR2*:​TRAF1:​TRAF2@Membrane map
  6. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
As Catalyser:
  1. FOS@Cytosol map → map FOS@Cytosol map
  2. JUND@Cytosol map → map JUND@Cytosol map
  3. JUN@Cytosol map → map JUN|​pho|​active@Cytosol map
  4. NFKBIA|​pho@Cytosol map → map degraded
  5. gMIF@Cytosol map → map rMIF@Cytosol map
  6. CHUK:​IKBKG:​IKK_beta_*@Cytosol map → map CHUK:​IKBKG|​ubi:​IKK_beta_*|​pho@Cytosol map
  7. MAP3K7@Cytosol map + TAB2@Cytosol map → map MAP3K7:​TAB2@Cytosol map
  8. gIRF1@Cytosol map → map rIRF1@Cytosol map
  9. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
  10. TRAF2@Cytosol map → map degraded
  11. gCCR2@Cytosol map → map rCCR2@Cytosol map
  12. gIFNA1@Cytosol map → map rINFA1@Cytosol map
  13. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map