Protein TRAF2 map

Identifiers
HUGO:TRAF2

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:21232017, PMID:21133840, PMID:18641653
TNF induces TRADD-dependent and RIPK1-dependent recruitment of TRAF2 to TNFR1.
TNFR2 interacts with TRAF2 and TRAF1.
PMID:24378531
TNF via TNFR2 ??induces??TRAF2??degradation.

TRAF2@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. TRAF2@Cytosol map
Participates in complexes:
In compartment: Membrane
  1. TNF:​TNFR2*:​TRAF1:​TRAF2@Membrane map
  2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map
  3. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
Participates in reactions:
As Reactant or Product:
  1. TNF@default map + TNFR1*@Membrane map + TRADD@Cytosol map + TRAF2@Cytosol map + RIPK1@Cytosol map + FADD@Cytosol map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map
  2. TNF@default map + TNFR2*@Membrane map + TRAF1@Cytosol map + TRAF2@Cytosol map → map TNF:​TNFR2*:​TRAF1:​TRAF2@Membrane map
  3. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
  4. TRAF2@Cytosol map → map degraded
As Catalyser:
  1. JUN@Cytosol map → map JUN|​pho|​active@Cytosol map
  2. NFKBIA|​pho@Cytosol map → map degraded
  3. CHUK:​IKBKG:​IKK_beta_*@Cytosol map → map CHUK:​IKBKG|​ubi:​IKK_beta_*|​pho@Cytosol map
  4. MAP3K7@Cytosol map + TAB2@Cytosol map → map MAP3K7:​TAB2@Cytosol map
  5. gIRF1@Cytosol map → map rIRF1@Cytosol map
  6. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
  7. TRAF2@Cytosol map → map degraded
  8. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map