Reaction translation re11 map

rTNF@Cytosol map → TNF@Cytosol map

Reaction regulators:
Catalysis
  1. MKNK1|​pho|​active@Cytosol map
Inhibition
  1. PPARG@Cytosol map
  2. IRF4@Cytosol map





Identifiers

Maps_Modules

References
PMID:22955274
MKNK1 (MNK1) regulates TNF mRNA polysome assembly
and upregulates TNF translation. IL-10 Inhibits TNF translation
through SHIP1-mediated Inhibition of MKNK1.
PMID:17681149
PPARG participates in inhibition of secretion of proinflammatory molecules, such as CCL-3, TNF, and MCP-1 (CCL-2).
PMID:16878026, PMID:14660645, PMID:15644117, PMID:10952726, PMID:23508573
Increased TNF expression downstream of HMGB1 is regulated via MYD88 and probably NFkB.