Identifiers
NAME:CHUK:IKBKG:IKK_beta_*
Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
References
complex
PMID???:15145317
The activated IKK complex,
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription
Identifiers
NAME:CHUK:IKBKG:IKK_beta_*
Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
References
complex
PMID???:15145317
The activated IKK complex,
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription
PMID:10521409, PMID:18802069
The endogenous IKK complex, overexpressed IKKs, and recombinant IKKbeta efficiently phosphorylated the Ser536 residue of p65 in vivo and in vitro,
that is important foe NFKB signaling activation.Ser536 is phoshorylated downstream of RAGE signaling in MDSC.