Complex MAP3K7:TAB2 map
Complex composition:

  1. MAP3K7 map
  2. TAB2 map

MAP3K7:​TAB2@Cytosol

Identifiers
NAME:MAP3K7:TAB2

Maps_Modules
MODULE:MACROPHAGE

References
PMID:14660645, PMID:18264787, PMID:12620219
IRAK-1 interacts with the downstream adaptor TRAF6,
resulting in formation of a complex that also includes TAK1 and TAB2.
IRAK-1 mediates the translocation of TRAF6, TAK1 and TAB2 to the cytosol,
where they form a multiprotein complex with other cytosolic proteins,
which are needed for stimulation of TAK1 kinase activity.
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1.

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. MAP3K7:​TAB2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. MAP3K7@Cytosol map + TAB2@Cytosol map → map MAP3K7:​TAB2@Cytosol map
As Catalyser:
  1. CHUK:​IKBKG:​IKK_beta_*@Cytosol map → map CHUK:​IKBKG|​ubi:​IKK_beta_*|​pho@Cytosol map