Protein TRADD map

Identifiers
HUGO:TRADD

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:14730360
TRADD is an adaptor molecule important for transducing signals from TNFR1. After binding of TNF, TRADD is recruited to TNFR1 and interacts with the cytoplasmic death domain region of TNFR1 through homotypic interactions. The TNFR1-TRADD complex serves as scaffolding for the recruitment of other signaling molecules that mediate the downstream actions of TNF.

TRADD@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. TRADD@Cytosol map
Participates in complexes:
In compartment: Membrane
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map
  2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
Participates in reactions:
As Reactant or Product:
  1. TNF@default map + TNFR1*@Membrane map + TRADD@Cytosol map + TRAF2@Cytosol map + RIPK1@Cytosol map + FADD@Cytosol map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map
  2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
As Catalyser:
  1. JUN@Cytosol map → map JUN|​pho|​active@Cytosol map
  2. CHUK:​IKBKG:​IKK_beta_*@Cytosol map → map CHUK:​IKBKG|​ubi:​IKK_beta_*|​pho@Cytosol map
  3. MAP3K7@Cytosol map + TAB2@Cytosol map → map MAP3K7:​TAB2@Cytosol map
  4. gIRF1@Cytosol map → map rIRF1@Cytosol map
  5. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
  6. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map