Protein FADD map

Identifiers
HUGO:FADD

Maps_Modules
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:MACROPHAGE

References
PMID:21133840, PMID:24378531
TNF acts through two transmembrane receptors: TNF receptor 1 (TNFR1), also known as p55 or p60, and TNF receptor 2 (TNFR2), also known as p75 or p80. Macrophages are reported to express both receptors.

Modifications:
In compartment: Cytosol
  1. FADD@Cytosol map
Participates in complexes:
In compartment: Membrane
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map
  2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
Participates in reactions:
As Reactant or Product:
  1. TNF@default map + TNFR1*@Membrane map + TRADD@Cytosol map + TRAF2@Cytosol map + RIPK1@Cytosol map + FADD@Cytosol map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map
  2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
As Catalyser:
  1. JUN@Cytosol map → map JUN|​pho|​active@Cytosol map
  2. CHUK:​IKBKG:​IKK_beta_*@Cytosol map → map CHUK:​IKBKG|​ubi:​IKK_beta_*|​pho@Cytosol map
  3. MAP3K7@Cytosol map + TAB2@Cytosol map → map MAP3K7:​TAB2@Cytosol map
  4. gIRF1@Cytosol map → map rIRF1@Cytosol map
  5. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
  6. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map