Reaction state_transition re296 map

CHUK:​IKBKG:​IKK_beta_*@Cytosol map → CHUK:​IKBKG|​ubi:​IKK_beta_*|​pho@Cytosol map

Reaction regulators:
Boolean_logic_gate_and
  1. RBCK1:​RNF31:​SHARPIN@Cytosol map and FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
Catalysis
  1. MAP3K7:​TAB2@Cytosol map
  2. RBCK1:​RNF31:​SHARPIN@Cytosol map
  3. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map





Identifiers

Maps_Modules

References
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1.
PMID:21232017, PMID:21133840, PMID:17301840
PMID:24958845, PMID:24699077
The LUBAC complex ubiquitinates NEMO, a subunit of the IKK complex downstream of TNF and upregulates IkBa degradetion.