Identifiers
HUGO:MYC
Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:CORE_SIGNALING_PATHWAYS
References
PMID:22067385
c-MYC expression is assosiated with M2 type of macrophages.
IL4 induces MYC expression in macrophages. MYC directly regulates some genes associated with alternative activation, including SCARB1, ALOX15, and MRC1, whereas others, including CD209, are indirectly regulated by c-MYC. c-MYC up-regulates the IL-4 signaling mediators signal transducer and activator of transcription-6 and peroxisome proliferator-activated receptor??, is also expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20581311
STAT3 as an essential mediator of emergency granulopoiesis by its regulation of transcription factors that direct G-CSF-responsive myeloid progenitor expansion.
STAT3 directly controls G-CSF-dependent expression of CCAAT-enhancer-binding protein ?? (C/EBP??), a crucial factor in the emergency granulopoiesis response. Moreover, STAT3 and C/EBP?? coregulate c-Myc through interactions with the c-myc promoter that control the duration of C/EBP?? occupancy during demand-driven granulopoiesis.
Identifiers
Maps_Modules
References