Protein FKBP8 map

Identifiers
FK506 binding protein 8, 38kDa
HUGO:FKBP8 HGNC:3724 ENTREZ:23770 UNIPROT:Q14318

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

FKBP8@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re998( Regulated Cell Death  map ):
PMID:17991864
FKBP8 antagonizes mTORC1, and mediates RHEB induced mTORC1 activation
rc_re999( Regulated Cell Death  map ):
RHEB competes with mTOR for FKBP8 binding, thus alleviating FKBP8-mediated inhibition of mTORC1

FKBP8@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re1000( Regulated Cell Death  map ):
influenceDelete: reactants to re
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:10409669
CASP3 mediated cleavage of BCL2 in vitro and in HL60 cells or MCF7 with reconstituted CASP3 expression after exposure to staurosporine
no cleavage by CASP7
PMID:20139069
FKBP8 protects BCL2 from CASP3-mediated degradation

Modifications:
In compartment: Cytosol
  1. FKBP8@Cytosol map
In compartment: Mitochondrial inner membrane
  1. FKBP8@Mitochondrial inner membrane map
Participates in complexes:
In compartment: Cytosol
  1. FKBP8:​RHEB|​pre@Cytosol map
  2. FKBP8:​RPTOR|​unk@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rc_s7967 + FKBP8@Cytosol map → map FKBP8:​RPTOR|​unk@Cytosol map
  2. FKBP8@Cytosol map + rc_s2052 → map FKBP8:​RHEB|​pre@Cytosol map
As Catalyser:
  1. BCL2|​unk@Mitochondrial inner membrane map → map cleaved~BCL2*@Mitochondrial inner membrane map