SP1

Protein SP1

Identifiers
secreted phosphoprotein 1
HUGO:SPP1 hgnc_id:HGNC:11255 HGNC:11255 ENTREZ:6696 UNIPROT:P10451
Sp1 transcription factor
HUGO:SP1, HGNC:11205, ENTREZ:6667, GENECARDS:GC12P053801, UNIPROT:P08047
HUGO:SP1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
EMT Senescence / EMT_REGULATORS
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / MIRNA_TF_IMMUNOSTIMULATORY

References
CASCADE:TGFB
PMID:18353785, PMID:23338822
SP1 regulates fibronectin expression downstream of TGFB signaling
PMID:23338822
collagen mRNA expression were also reduced by 48% in the transfection SP1 decoy ODN group.
Suppression of cell proliferation by Sp1 decoy ODNs
PMID:10964912
SP1 probably upregulates integrin b5 expression in fibroblasts downstream of TGFB (condurmed for osteoblastic cells only)
PMID:15001984
Smad3 complex interact with SP1 and ETS1 and induces activity of TN-C promoter.
PMID:11007770
Synergistic Cooperation between Sp1 and Smad3/Smad4 Mediates Transforming Growth Factor ??1 Stimulation of ??2(I)-Collagen (COL1A2) Transcription in fibroblasts
PMID:21252118
OPN promotes tumor progression via the transformation of MSC into CAF.
PMID:11013220
Cooperation and physical interaction of Smad2, Smad3, Smad4 with SP1 at the promoter of CDKN2B (p15INK4B) gene
This interaction provides a mechanism underlying the TGFB-induced growth arrest
NATURAL_KILLER
CASCADE:IL12
PMID:17705132
SP1 directly activate TBX21 (T-Bet) promoter in NK cells downstream of IL12, IL15.
Mithramycin A inhibits while monokines increase Sp1 binding to T-BET promoter and
downregulates T-BET and IFNG expression in NK cells.

SP1@Nucleus

References
em_emtc_emtc_re1231( EMT Senescence ):
PMID:16079281
Phosphorylation of Sp-1 by ERK provokes an increase in the transcriptional activity of Sp1- dependent genes

SP1|pho|active@Nucleus

References
em_emtc_emtc_re1231( EMT Senescence ):
PMID:16079281
Phosphorylation of Sp-1 by ERK provokes an increase in the transcriptional activity of Sp1- dependent genes
em_emtc_emtc_re65( EMT Senescence ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
MMP-9 transcription is activated in response to Snail expression
Oncogenic H-Ras (RasV12) synergistically co-operates with Snail in the induction of MMP-9 transcription and expression.
Phosphorylated Sp-1 is recruited to the MMP-9 promoter following activation of the Erk1/2 pathway
PMID:19564415
The transcription factor FOXO3, negatively regulated by binding to 14-3-3 protein family, induces MMP9 and MMP13 expression.
This explains the role of FOXO3 in promoting tumor invasion.
PMID:22439866
c-Myb strongly increased the expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 and significantly downregulated MMP1.
PMID:8844971
Molecular mechanism of transcriptional activation of human gelatinase B (=MMP9) by proximal promoter. (NFKB)
PMID:16556862
ROS regulate MMP gene expression and activation of proenzymes. MMP-1, MMP-2, MMP-7, and MMP-9 are activated by ROS through interactions with thiol groups
em_emtc_emtc_re67( EMT Senescence ):
PMID:15592504
PMID:16716598
SP1 and HIF1 complex (HIF2_alpha_ and HIF1_beta_) cooperatively induce MMP1 transcriptional expression
PMID:20589835
Our results indicate that MT1-MMP is a direct down-stream target in the Wnt signaling pathway, and that one of the ways accumulated beta-catenin contributes to colorectal carcinogenesis is by transactivating this gene.
MT1-MMP is one target gene of Lef-1/Tcf-4 (Takahashi et al, 2002)
NF-??B is an important transcriptional factor of MT1-MMP expression
em_emtc_emtc_re283( EMT Senescence ):
PMID:11114293
Sp1 and Smad proteins form complexes and their synergy plays an important role in mediating TGFB1-induced 2(I) collagen expression in human mesangial cells.
Involvement of Sp1 binding in Smad3-mediated TGFB1 induction of COL1A2
Sp1 and Smad proteins bind to the COL1A2 promoter
TGFB1 increases association between Sp1 and Smad proteins
Sp1 and Smad3 cooperate to regulate COL1A2 expression
em_emtc_emtc_re1225( EMT Senescence ):
PMID:17490644
Snai1 and TCF3 (E47) upregulate both mRNA and protein level of ID1
This upregulation depends on SP1 or AP1 co-transcription factors
Erk contributes to the recruitment or assembly of proteins to Id-1 promoter
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression

Modifications:
In compartment: Cytosol

SP1@Cytosol

In compartment: INNATE_IMMUNE_CELL_Cytosol

SP1@INNATE_IMMUNE_CELL_Cytosol

In compartment: Nucleus

SP1@Nucleus
SP1|pho|active@Nucleus

Participates in complexes:
In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: