RNA FN* map

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map

References
CASCADE:HH
PMID:23031257
TGF-??1???Induced Fibroblast Differentiation Depends on SMO in Control Fibroblasts
Expression of collagen and actin (alphaSMA) and FN1 are SMO and GLI1/GLI2 dependent
PMID:21674557
Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts.
This effect is mediated by up-regulation of specific genes related to a myo/contractile phenotype (ACTA2, CNN1,FN (ED-A containing), EDN1, MYL12A, TAGLN2) and inhibition of ACTG2 expression.

Modifications:
In compartment: Cytosol
  1. rFN*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gFN*@Cytosol map → map rFN*@Cytosol map
    2. rFN*@Cytosol map → map FN*@Cytosol map
    As Catalyser: