Reaction transcription em_emtc_emtc_re283 map

gCOL1A2@Nucleus map → rCOL1A2@Nucleus map

Reaction regulators:
Physical_stimulation
  1. SP1|​pho|​active@Nucleus map
  2. SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4:​SP1@Nucleus map


Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:11114293
Sp1 and Smad proteins form complexes and their synergy plays an important role in mediating TGFB1-induced 2(I) collagen expression in human mesangial cells.
Involvement of Sp1 binding in Smad3-mediated TGFB1 induction of COL1A2
Sp1 and Smad proteins bind to the COL1A2 promoter
TGFB1 increases association between Sp1 and Smad proteins
Sp1 and Smad3 cooperate to regulate COL1A2 expression