Boolean_logic_gate_and

1. TCF3@Nucleus and SP1|​pho|​active@Nucleus

Inhibition

1. HMGA2:​SMAD2_3*:​SMAD4@Nucleus
2. ATF3:​SMAD2_3*:​SMAD4@Nucleus

Physical_stimulation

1. SP1|​pho|​active@Nucleus
2. SNAI1@Nucleus
3. TCF3@Nucleus

References
PMID:17490644
Snai1 and TCF3 (E47) upregulate both mRNA and protein level of ID1
This upregulation depends on SP1 or AP1 co-transcription factors
Erk contributes to the recruitment or assembly of proteins to Id-1 promoter
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression