Protein SPP1 map

Identifiers
secreted phosphoprotein 1
HUGO:SPP1 hgnc_id:HGNC:11255 HGNC:11255 ENTREZ:6696 UNIPROT:P10451

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map

References
CASCADE:PDGF
PMID:19118022
fibroblasts expressed high amounts of osteopontin, and stimulation with PDGF-CC for 6 h increased the production even further, by 2.4-fold compared to unstimulated fibroblasts, demonstrating that the expression of osteopontin is directly regulated by signaling induced by PDGF-CC in fibroblasts.
PMID:20138012
SPP1 (OPN) , COX2, CXCL1, CXCL2, CYR61, IL1B, IL6 genes are upregulated in CAFs
PMID:25099519
Tumor ??9??1 integrin, contributes to tumor growth, lymphatic metastasis, recruitment of cancer-associated fibroblasts (CAFs), and host-derived OPN production. We also found that CAFs contributed to tumor growth, lymphatic metastasis, and host-derived OPN levels. Consistent with those findings, tumor volume was well-correlated with numbers of CAFs and levels of host-derived OPN. Furthermore, it was shown that the inoculation of D3H2LN cells into mammary fat pads with mouse embryonic fibroblasts (MEFs), obtained from wild type, but not OPN knock-out mice, resulted in enhancement of tumor growth, thus indicating that CAF-derived OPN enhanced tumor growth.

Modifications:
In compartment: Cytosol
  1. SPP1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. SPP1@Cytosol map → map SP1@Cytosol map
    2. rSPP1@Cytosol map → map SPP1@Cytosol map
    3. SPP1@Cytosol map → map TUMOR_GROWTH@default map
    4. SPP1@Cytosol map → map Angiogenesis@default map
    As Catalyser: