Gene ITGA11 map

Identifiers
HUGO:ITGA11
integrin, alpha 11
HUGO:ITGA11 HGNC:6136 ENTREZ:22801 UNIPROT:Q9UKX5

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map

References
CASCADE:TGFB
CASCADE:INTEGRIN
PMID:20129924; PMID:19913614
The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.
Transfection and expression of the inhibitory Smad7 in the cells attenuated the TGF-beta1-dependent alpha11 induction both at the RNA and the protein level. Mutation and deletion analyses identified a Smad-binding element, SBE2 (nt -182/-176), as an important Smad3-binding site in this part of the promoter. Further analyses suggested that the Sp1-binding site SBS1 (nt -140/-134) takes part in the responsiveness to TGF-beta1 in a Smad2-dependent manner.

Modifications:
In compartment: Cytosol
  1. gITGA11@Cytosol map
In compartment: Nucleus
  1. gITGA11@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gITGA11@Cytosol map → map rITGA11@Cytosol map
    2. gITGA11@Nucleus map → map rITGA11@Nucleus map
    As Catalyser: