Protein PRKCZ map

Identifiers
protein kinase C, zeta
HUGO:PRKCZ HGNC:9412 ENTREZ:5590 UNIPROT:Q05513

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

PRKCZ@Cytosol

References
em_emtc_emtc_re772( EMT Senescence  map ):
RAC1 binds directly to PARD6 that activates PRKCZ.
This leads to establishment of the cell polarity and promotes cellular transformation.
PMID:10873802
PARD6 links Rac1 and Cdc42 to PKCzeta signaling and cell transformation.
PMID:10934475
PARD6 binds to Cdc42; Rac1; PARD3; PRKC isoforms.
In vitro, PARD3 acts as a substrate and an inhibitor of PRKC.
PARD3 and PARD6 have a scaffolding function, coordinating the activities of several signalling proteins that are implicated in mammalian cell polarity.
PMID:10954424
PARD6 is a binding partner for the Rho GTPases Cdc42 and Rac1
em_emtc_emtc_re774:( EMT Senescence  map ) PMID:20505164

Modifications:
In compartment: Cytosol
  1. PRKCZ@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PKC*@Cytosol map → map PRKCZ@Cytosol map
    2. PRKCZ@Cytosol map → map PRKCZ@Cytosol map
    3. PRKCZ@Cytosol map → map Epithelial polarity@Nucleus map
    As Catalyser:
    1. BAX@Cytosol map → map BAX|​S184_pho@Cytosol map
    2. Caspase9*|​S196_unk|​T125_unk|​Y153_unk@Cytosol map → map Caspase9*|​S196_unk|​T125_unk|​S144_pho|​Y153_unk@Cytosol map