Protein CIP1_KIP1* map

Identifiers
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
HUGO:CDKN1A, HGNC:1784, ENTREZ:1026, UNIPROT:P38936
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
HUGO:CDKN1B, HGNC:1785, ENTREZ:1027, UNIPROT:P46527
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
HUGO:CDKN1C, HGNC:1786, ENTREZ:1028, UNIPROT:P49918

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G1_CC_PHASE  map
 Cell Cycle DNA Repair  map  / S_CC_PHASE  map

References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786

CIP1_KIP1*@Nucleus

References
ce_re345:( Cell Cycle DNA Repair  map ) CHECKPOINT is p53_dependent_G1_S_checkpoint
ce_re115( Cell Cycle DNA Repair  map ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
ce_re120( Cell Cycle DNA Repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141

Modifications:
In compartment: Nucleus
  1. CIP1_KIP1*@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. CIP1_KIP1*:​PARP1@Nucleus map
  2. CIP1_KIP1*:​CyclinE*@Nucleus map
  3. CIP1_KIP1*:​CyclinA1*@Nucleus map
  4. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus map + CIP1_KIP1*@Nucleus map → map (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus map
  2. CIP1_KIP1*@Nucleus map + ce_s3119 → map CIP1_KIP1*:​CyclinE*@Nucleus map
  3. CIP1_KIP1*@Nucleus map + ce_s3123 → map CIP1_KIP1*:​CyclinA1*@Nucleus map
  4. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus map → map CIP1_KIP1*@Nucleus map + (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus map
  5. CIP1_KIP1*:​CyclinE*@Nucleus map → map ce_s3119 + CIP1_KIP1*@Nucleus map
  6. CIP1_KIP1*:​CyclinA1*@Nucleus map → map ce_s3123 + CIP1_KIP1*@Nucleus map
  7. CIP1_KIP1*@Nucleus map → map degraded
  8. rCIP/KIP*@Nucleus map → map CIP1_KIP1*@Nucleus map
  9. CIP1_KIP1*@Nucleus map + PARP1|​PolyADPribose_unk|​pho@Nucleus map → map CIP1_KIP1*:​PARP1@Nucleus map
As Catalyser:
  1. G1 phase@Nucleus map → map S phase@Nucleus map
  2. G2 phase@Nucleus map → map M phase@Nucleus map
  3. E2F1:​RB1@Nucleus map → map E2F1:​RB1|​pho@Nucleus map
  4. E2F4_5*:​p107*@Nucleus map → map E2F4_5*:​p107*|​pho@Nucleus map