Protein CBP* map

Identifiers
HUGO:CREBBP

Maps_Modules
MODULE:MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:19879327
STAT1 is acetylated by CBP at the lysine residues K410 and K413.
PMID:16007092
GSK3B induces RELA (p65) interaction with CBP and activates downstream NF-kB signaling end expression of proinflammatory cytokines.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
PMID:12417340
IRF-1 can be acetylated by p300. p300 is recruited to the IL-12p40 promoter depending on both ICSBP and IRF-1
and acts as coactivator in macrophages.

CBP*@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. CBP*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CBP*:​RELA@Cytosol map
  2. CBP*:​CREB1|​pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CBP*@Cytosol map + RELA@Cytosol map → map CBP*:​RELA@Cytosol map
  2. CREB1|​pho|​active@Cytosol map + CBP*@Cytosol map → map CBP*:​CREB1|​pho@Cytosol map
As Catalyser:
  1. STAT1|​pho|​active@Cytosol map → map STAT1|​pho|​ace@Cytosol map
  2. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map
  3. CBP*@Cytosol map + RELA@Cytosol map → map CBP*:​RELA@Cytosol map
  4. gIL12p40*@Cytosol map → map rIL12p40*@Cytosol map
  5. IRF1@Cytosol map → map IRF1|​ace@Cytosol map