Phenotype M1 phenotype of macrophages map
M1 phenotype of macrophages@Cytosol

Identifiers

Maps_Modules
MODULE:MACROPHAGE

References
PMID:20856220
These cells are characterized by their ability
to release large amounts of proinflammatory cytokines (such as IL-12,
IL-23 and tumor necrosis factor (TNF)), reactive nitrogen intermediates
and reactive oxygen intermediates, higher expression of
major histocompatibility complex class II and costimulatory molecules, efficient
antigen presentation, and microbicidal or tumoricidal activity.
M1 macrophages are part of a polarized TH1 response and mediate resistance
to intracellular pathogens and tumors and elicit tissue-disruptive reaction.
PMID:1431106
Classical activation of macrophages (M1) induces macrophage
tumoricidal activity
PMID:20338029
The M1 form of tumor-associated macrophages in tumor
is positively associated with survival time.
PMID:19029990
M1 (classical) activation require both IFNG and TNF. TLR ligand acting in a MyD88-dependent manner will induce the transcription of TNF,
which can then cooperate with IFN??in an autocrine manner to activate this macrophage population??
PMID:1679046
Activated monocytes bound to a monolayer of tumor cells more
than resting mononuclear phagocytes.

Modifications:
In compartment: Cytosol
  1. M1 phenotype of macrophages@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. ROS production@Cytosol map → map M1 phenotype of macrophages@Cytosol map
    2. M1 phenotype of macrophages@Cytosol map → map Tumor cell death@default map
    3. NFKB1_p50*:​RELA|​pho@Cytosol map → map M1 phenotype of macrophages@Cytosol map
    4. NO production@Cytosol map → map M1 phenotype of macrophages@Cytosol map
    5. M1 phenotype of macrophages@Cytosol map → map Antitumor activity@default map
    As Catalyser: