Identifiers
HUGO:NOS2
Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:NO_ROS_PRODUCTION
References
PMID:17476345
NOS2, a heme-containing enzyme
that catalyzes the synthesis of NO and citrulline from l???Arg, is
expressed by various cells of the immune system, and its activa-
tion is considered a hallmark of classically activated macrophages
(also known as M1 macrophages), a macrophage subset that pro-
duces proinflammatory cytokines and acts as the effector cell in
the killing of invading pathogens and tumor cells.
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters
and transrepresses NF-kB dependent expression NOS2, Ccl3, Ccl7, Cxcl10
PMID:17689680
STAT1 binds to INOS promoter and induces INOS expression and NO production downstream of IFNG in murine macrophages. Acetylation inhibits STAT1 binding to promotor.
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
PMID:22067385
c-MYC is expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGF??, VEGF.
PMID: 16424049
iNOS expression was induced by IFN-gamma stimulation in MDSC, probably via STAT1.
Identifiers
Maps_Modules
References