Protein FANCL map

Identifiers
Fanconi anemia, complementation group L
HUGO:FANCL, HGNC:20748, ENTREZ:55120, UNIPROT:Q9NW38

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / FANCONI  map
 Cell Cycle DNA Repair  map  / TLS  map

References
The enzyme possesses E3 ubiquitin ligase activity, the active part in the Fanconi core complex
PMID:19686080, PMID:19622404, PMID:18931676
FA core complex regulates REV1 and activated TLS
PMID:22266823

FANCL@Nucleus

References
ce_re213( Cell Cycle DNA Repair  map ):
PMID:19264559
FANCL induces UBE2T auto-ubiquitination on Lys91 by this inactivating UBE2T. This is a negative loop:
PMID:16916645

Modifications:
In compartment: Nucleus
  1. FANCL@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. FAAP100*:​FANCB:​FANCL@Nucleus map
  2. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​TOP3A@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. FANCB@Nucleus map + FANCL@Nucleus map + FAAP100*@Nucleus map → map FAAP100*:​FANCB:​FANCL@Nucleus map
  2. FANCA|​pho:​FANCG|​S7_pho@Nucleus map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@Nucleus map + FAAP24*:​FANCM@Nucleus map + FAAP100*:​FANCB:​FANCL@Nucleus map + BLM@Nucleus map + HES1@Nucleus map + FAAP20*@Nucleus map → map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus map + TOP3A@Nucleus map + RPA1:​RPA2:​RPA3@Nucleus map → map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​TOP3A@Nucleus map
As Catalyser:
  1. gFanconi_DNA_st2*@Nucleus map → map gFanconi_DNA_st3*@Nucleus map
  2. FANCD2|​pho@Nucleus map → map FANCD2|​K561_ubi|​pho@Nucleus map
  3. FANCI|​pho@Nucleus map → map FANCI|​K523_ubi|​pho@Nucleus map
  4. gFanconi_DNA_st4*@Nucleus map → map gFanconi_DNA_st5*@Nucleus map
  5. FANCD2@Nucleus map → map FANCD2|​pho@Nucleus map
  6. FANCD2|​K561_ubi|​pho@Nucleus map + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus map
  7. UBE2T@Nucleus map → map UBE2T|​k91_ubi@Nucleus map
  8. gTLS_DNA_st1*@Nucleus map → map gTLS_DNA_st2*@Nucleus map