Protein NTN1 map

Identifiers
netrin 1
HUGO:NTN1 HGNC:8029 ENTREZ:9423 UNIPROT:O95631

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
PMID:20495383
PMID:20173780
PMID:19543238
PMID:22920895
Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H

NTN1@Extracellular space

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1698( Regulated Cell Death  map ):
PMID:19543238
PMID:21172653
The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1

Modifications:
In compartment: Extracellular space
  1. NTN1@Extracellular space map
Participates in complexes:
In compartment: Cytosol
  1. NTN1:​UNC5A@Cytosol map
  2. Caspase3*:​DCC:​NTN1@Cytosol map
  3. CIP2A*:​DAPK1|​pho:​NTN1:​UNC5B@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Caspase3*:​DCC:​NTN1@Cytosol map → map NTN1@Extracellular space map + Cleaved DCC*@Cytosol map
  2. CIP2A*:​DAPK1|​pho:​NTN1:​UNC5B@Cytosol map + PPP2CB:​PPPR1B@Cytosol map → map NTN1@Extracellular space map + DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol map + CIP2A*@Cytosol map
  3. NTN1:​UNC5A@Cytosol map → map NRAGE*:​UNC5A@Cytosol map + NTN1@Extracellular space map
As Catalyser: