Protein PTP4A3 map

Identifiers
HUGO:PTP4A3
protein tyrosine phosphatase type IVA, member 3
HUGO:PTP4A3 HGNC:9636 ENTREZ:11156 UNIPROT:O75365

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.
http://d-scholarship.pitt.edu/18634/1/Zimmerman_ETD-2013.pdf
c-MYC activity was able to increase Ptp4a3 gene expression in a fibroblast cell culture model.
Tumors from the Ptp4a3-null mice had elevated levels of both IGF1R?? and c-MYC compared to tumors replete with PTP4A3.
Ptp4a3-null cells displayed less migration compared to wildtype cells and loss of VEGF-induced phosphorylation of SRC protein.
Reduced migration and SRC activation were also observed when human endothelial cells were treated with a small molecule inhibitor of PTP4A3.

PTP4A3|​pre@Cytosol

References
mo_re95:( motility  map ) PMID:23178297

PTP4A3|​Y53_unk|​pre@Cytosol

References
mo_re292:( motility  map ) PMID:22995644

PTP4A3|​Y53_pho|​pre|​active@Cytosol

References
mo_re8:( motility  map ) PMID:23691193 PMID:25687758 PMID:22677902
mo_re14:( motility  map ) PMID:18268019 PMID:23691193 PMID:17192274 PMID:22677902
mo_re15:( motility  map ) PMID:17192274 PMID:22677902 PMID:27452906 PMID:24030100
mo_re30:( motility  map ) PMID:17409395
mo_re32:( motility  map ) PMID:17192274 PMID:27036022
mo_re54:( motility  map ) PMID:16540666 PMID:20681446
mo_re55:( motility  map ) PMID:16540666 PMID:22825514

PTP4A3@Cytosol

References
mo_re284:( motility  map ) PMID:27588115

PTP4A3@Nucleus

References
mo_re230:( motility  map ) PMID:24686170

PTP4A3|​pre@Nucleus

References
mo_re83:( motility  map ) PMID:21725609 PMID:23178297 PMID:23572150

PTP4A3|​pre@Early endosome

References
mo_re36:( motility  map ) PMID:18078820 PMID:22137788
mo_re121:( motility  map ) PMID:21806020

PTP4A3|​Y53_unk|​pre@Early endosome

References
mo_re74:( motility  map ) PMID:20609352 PMID:27328425
mo_re1:( motility  map ) PMID:21084277 PMID:19440036 PMID:19945467 PMID:20609352 PMID:26597054 PMID:17409395 PMID:27328425 PMID:27572739 PMID:24030100
mo_re29:( motility  map ) PMID:19440036 PMID:17409395 PMID:24696260
mo_re190:( motility  map ) PMID:21084277 PMID:19440036 PMID:19945467 PMID:26597054 PMID:17409395 PMID:27328425 PMID:27572739
mo_re287:( motility  map ) PMID:25136802

PTP4A3|​Y53_pho|​pre|​active@Endoplasmic reticulum

References
mo_re171:( motility  map ) PMID:25687758

PTP4A3|​pre@Golgi apparatus

References
mo_re79:( motility  map ) PMID:22595524

PTP4A3|​pho|​active@Cytosol

References
em_emtc_emtc_re1627( EMT Senescence  map ):
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.
http://d-scholarship.pitt.edu/18634/1/Zimmerman_ETD-2013.pdf
c-MYC activity was able to increase Ptp4a3 gene expression in a fibroblast cell culture model.
Tumors from the Ptp4a3-null mice had elevated levels of both IGF1R?? and c-MYC compared to tumors replete with PTP4A3.
Ptp4a3-null cells displayed less migration compared to wildtype cells and loss of VEGF-induced phosphorylation of SRC protein.
Reduced migration and SRC activation were also observed when human endothelial cells were treated with a small molecule inhibitor of PTP4A3.
em_emtc_emtc_re1( EMT Senescence  map ):
PMID:20731704
PMID:21317430
In NMuMG cells treated with TGFB1 Snail1 RNA and protein are induced 1 h after addition of the cytokine preceding Zeb1 up-regulation that requires 6???8 h.
Zeb1 gene expression is caused by increased RNA levels but also by enhanced protein stability and is markedly dependent on Snail1 because depletion of this protein prevents Zeb1 protein and RNA up-regulation
PMID:22406545
TGFB can activate both SNAI1 and SNAI2 and thus promote EMT via both SMAD-dependent and -independent pathways
PMID:16617148
Negative feedback by SNAI1 itself
PMID:17671186
KLF8 directly bound to the promotor of Snail and repressed Snail expression
PMID:17563753
Snail promoter is regulated positively by NFkB_p65
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression
em_emtc_emtc_re177( EMT Senescence  map ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:7512751
PMID:7528107
Integrin aVb3 plays an important role in angiogenesis. Bblocking of the binding of endothelial integrin aVb3 inhibits angiogenesis and forces neovascular ECs into apoptosis (Brooks et al., 1994a,b).

Modifications:
In compartment: Cytosol
  1. PTP4A3@Cytosol map
  2. PTP4A3|​pre@Cytosol map
  3. PTP4A3|​pho|​active@Cytosol map
  4. PTP4A3|​Y53_unk|​pre@Cytosol map
  5. PTP4A3|​Y53_pho|​pre|​active@Cytosol map
In compartment: Early endosome
  1. PTP4A3|​pre@Early endosome map
  2. PTP4A3|​Y53_unk|​pre@Early endosome map
In compartment: Endoplasmic reticulum
  1. PTP4A3|​Y53_pho|​pre|​active@Endoplasmic reticulum map
In compartment: Golgi apparatus
  1. PTP4A3|​pre@Golgi apparatus map
In compartment: Nucleus
  1. PTP4A3@Nucleus map
  2. PTP4A3|​pre@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. JAM2:​PTP4A3@Cytosol map
  2. PTP4A3|​pre:​RAP1*@Cytosol map
  3. ITGB1|​Y783_pho:​PTP4A3@Cytosol map
In compartment: Golgi apparatus
  1. ARF1:​GTP:​PTP4A3|​pre@Golgi apparatus map
In compartment: Recyclying endosome
  1. ARF1:​GTP:​PTP4A3|​pre@Recyclying endosome map
Participates in reactions:
As Reactant or Product:
  1. rPTP4A3@Nucleus map → map PTP4A3@Cytosol map
  2. PTP4A3@Cytosol map → map PTP4A3|​pho|​active@Cytosol map
  3. PTP4A3|​pre@Cytosol map → map PTP4A3@Nucleus map
  4. mo_s363 → map mo_s743 + PTP4A3@Cytosol map
  5. mo_s338 + PTP4A3@Cytosol map → map ITGB1|​Y783_pho:​PTP4A3@Cytosol map
  6. ITGB1|​Y783_pho:​PTP4A3@Cytosol map → map mo_s363
  7. PTP4A3|​Y53_pho|​pre|​active@Cytosol map → map PTP4A3|​Y53_pho|​pre|​active@Endoplasmic reticulum map
  8. PTP4A3@Nucleus map → map Actin fibers disassembly@Nucleus map
  9. PTP4A3@Nucleus map → map F-actin???rich membrane protrusions@Cytosol map
  10. PTP4A3@Nucleus map → map PTP4A3|​pre@Golgi apparatus map
  11. ARF1:​GTP:​PTP4A3|​pre@Golgi apparatus map → map ARF1:​GTP:​PTP4A3|​pre@Recyclying endosome map
  12. ARF1:​GTP:​PTP4A3|​pre@Recyclying endosome map → map ITGA5 & TFRC recycling@Cytosol map
  13. PTP4A3|​Y53_pho|​pre|​active@Cytosol map → map Actin fibers disassembly@Cytosol map
  14. rPTP4A3@Nucleus map → map PTP4A3@Nucleus map
  15. PTP4A3@Cytosol map + JAM2@Cytosol map → map JAM2:​PTP4A3@Cytosol map
  16. JAM2:​PTP4A3@Cytosol map → map Cell adhesion@default map
  17. PTP4A3|​Y53_unk|​pre@Early endosome map → map Autophagy@Cytosol map
  18. BCR-ABL signalling@Cytosol map → map PTP4A3|​Y53_unk|​pre@Cytosol map
  19. PTP4A3|​Y53_unk|​pre@Cytosol map → map Proliferation@Cytosol map
  20. PTP4A3|​Y53_unk|​pre@Cytosol map → map PTP4A3|​Y53_unk|​pre@Early endosome map
  21. PTP4A3|​pre@Cytosol map → map PTP4A3|​Y53_unk|​pre@Cytosol map
  22. PTP4A3|​pre@Cytosol map → map degraded
  23. PTP4A3|​Y53_pho|​pre|​active@Cytosol map → map EMT & motility@Cytosol map
  24. PTP4A3@Cytosol map → map PTP4A3@Cytosol map
  25. PTP4A3@Cytosol map → map PTP4A3@Cytosol map
  26. PTP4A3@Cytosol map → map PTP4A3@Cytosol map
  27. PTP4A3@Cytosol map → map PTP4A3@Cytosol map
  28. PTP4A3@Cytosol map → map PTP4A3@Cytosol map
  29. PTP4A3|​pre@Cytosol map → map PTP4A3|​pre@Early endosome map
  30. PTP4A3@Nucleus map → map PTP4A3@Cytosol map
  31. PTP4A3@Cytosol map → map PTP4A3@Nucleus map
  32. PTP4A3@Nucleus map → map PTP4A3@Nucleus map
  33. PTP4A3@Nucleus map → map PTP4A3@Nucleus map
  34. PTP4A3|​pre@Cytosol map → map PTP4A3|​pre@Cytosol map
  35. PTP4A3@Nucleus map → map PTP4A3@Nucleus map
  36. PTP4A3@Nucleus map → map PTP4A3@Nucleus map
  37. PTP4A3@Nucleus map → map PTP4A3@Nucleus map
  38. PTP4A3@Nucleus map → map PTP4A3@Nucleus map
  39. PTP4A3@Nucleus map → map PTP4A3@Nucleus map
  40. PTP4A3|​pre@Cytosol map → map PTP4A3|​pre@Nucleus map
  41. PTP4A3@Nucleus map → map PTP4A3|​Y53_unk|​pre@Early endosome map
  42. PTP4A3|​pre@Golgi apparatus map + mo_s204 → map ARF1:​GTP:​PTP4A3|​pre@Golgi apparatus map
  43. PTP4A3@Cytosol map → map PTP4A3|​Y53_pho|​pre|​active@Cytosol map
  44. PTP4A3|​pre@Nucleus map + RAP1*@Nucleus map → map PTP4A3|​pre:​RAP1*@Cytosol map
  45. PTP4A3|​pre:​RAP1*@Cytosol map → map PTP4A3|​pre@Cytosol map + RAP1*@Cytosol map
As Catalyser:
  1. gSNAI1@Nucleus map → map rSNAI1@Nucleus map
  2. gTIMP2@Nucleus map → map rTIMP2@Nucleus map
  3. MMP2@Extracellular space map → map MMP2*@Extracellular space map
  4. gPlakoglobin*@Nucleus map → map rPlakoglobin*@Nucleus map
  5. gITGB3@Nucleus map → map rITGB3@Nucleus map
  6. gE-Cadherin*@Nucleus map → map rE-Cadherin*@Nucleus map
  7. gFibronectin*@Nucleus map → map rFibronectin*@Nucleus map
  8. PTEN|​pho|​active@Cytosol map → map PTEN@Cytosol map
  9. PXN|​pho|​active@Cytosol map → map PXN@Cytosol map
  10. FAK*|​pho|​active@Cytosol map → map FAK*@Cytosol map
  11. JMJD1B*@Nucleus map → map JMJD1B*@Nucleus map
  12. JMJD2B*@Nucleus map → map JMJD2B*@Nucleus map
  13. rVimentin*@Nucleus map → map Vimentin*@Cytosol map
  14. rCytokeratin*@Nucleus map → map Cytokeratin*@Cytosol map
  15. r??-Catenin*@Nucleus map → map ??-Catenin*@Cytosol map
  16. PI4,5-P2@Early endosome map → map PIP@Early endosome map
  17. gEGR1@Nucleus map → map rEGR1@Nucleus map
  18. ERK*@Cytosol map → map ERK*|​pho@Cytosol map
  19. KRT8|​S73_pho|​S431_pho@Cytosol map → map KRT8@Cytosol map
  20. eIF2*@Cytosol map → map eIF2*|​Ser51_pho|​active@Cytosol map
  21. mo_s780 → map mo_s338
  22. Src@Cytosol map → map Src|​Tyr527_pho@Cytosol map
  23. gMMP2@Nucleus map → map rMMP2@Nucleus map
  24. gTIMP2@Nucleus map → map rTIMP2@Nucleus map
  25. HSP60*:​ULBP2@Endoplasmic reticulum map → map HSP60*|​pho:​ULBP2@Endoplasmic reticulum map
  26. Rag A/B*:​Rag C/D*@Cytosol map + mo_s16 → map GDP:​GTP:​MLST8:​MTOR:​RPTOR:​Rag A/B*:​Rag C/D*@Lysosome map
  27. PI3K*@Cytosol map → map PI3K*@Cytosol map
  28. rPTEN@Nucleus map → map PTEN@Nucleus map
  29. gStathmin*@Nucleus map → map rStathmin*@Nucleus map
  30. Stathmin*|​pho@Cytosol map → map Stathmin*@Cytosol map
  31. gPTP1B*@Nucleus map → map rPTP1B*@Nucleus map
  32. NHERF1*|​pho@Nucleus map → map NHERF1*@Nucleus map
  33. JMJD2C*@Nucleus map + Histone H3*|​K9_met|​K9_met|​K9_met:​LEO1 promoter*@Nucleus map → map Histone H3*|​K9_met|​K9_met|​K9_met:​JMJD2C*:​LEO1 promoter*@Nucleus map
  34. Histone H3*|​K9_met|​K9_met|​K9_met:​JMJD2C*:​LEO1 promoter*@Nucleus map → map Histone H3*|​K9_met|​K9_met:​JMJD2C*:​LEO1 promoter*@Nucleus map
  35. Histone H3*|​K9_met|​K9_met|​K9_met:​JMJD2C*:​LEO1 promoter*@Nucleus map → map Histone H3*|​K9_met:​JMJD2C*:​LEO1 promoter*@Nucleus map
  36. mo_s204 + GGA1@Cytosol map → map ARF1:​GGA1:​GTP@Golgi apparatus map
  37. ITGA5@Cytosol map → map ITGA5@Recyclying endosome map
  38. TFRC@Cytosol map → map TFRC@Recyclying endosome map
  39. mo_s88 → map mo_s75
  40. others*@Cytosol map + Vinculin*@Cytosol map + PXN|​pho|​active@Cytosol map + FAK*|​pho|​active@Cytosol map → map FAK*|​pho:​PXN|​pho:​Vinculin*:​others*@Cytosol map
  41. gMMP9@Nucleus map → map rMMP9@Nucleus map
  42. MMP14@Cytosol map → map MMP14@Cytosol map
  43. gMMP10@Nucleus map → map rMMP10@Nucleus map
  44. rRHOA@Nucleus map → map RHOA@Nucleus map
  45. rRAC*@Nucleus map → map RAC*@Nucleus map
  46. VEGF*:​VEGFR2@Cytosol map → map VEGF*:​VEGFR2|​pho@Cytosol map
  47. TNF??*@default map + TNF-R1*@Cytosol map → map TNF-R1*:​TNF??*@Cytosol map
  48. gIL-4*@Nucleus map → map rIL-4*@Nucleus map
  49. rE-cadherin*@Nucleus map → map E-cadherin*@Cytosol map
  50. JNK*@Nucleus map → map JNK*|​pho|​active@Nucleus map
  51. gp14ARF*@Nucleus map → map rp14ARF*@Nucleus map
  52. GTP:​RAC1@Cytosol map → map GDP:​RAC1@Cytosol map
  53. gCCL26@Nucleus map → map rCCL26@Nucleus map
  54. STAT3@Cytosol map → map STAT3|​Y527_pho|​active@Cytosol map
  55. EZR|​Thr 567_pho|​active@Cytosol map → map EZR@Cytosol map
  56. gERK1_2*@Nucleus map → map rERK1_2*@Nucleus map
  57. ERK1_2*@Nucleus map → map ERK1_2*|​pho|​active@Nucleus map
  58. mo_s95 → map mo_s96
  59. mo_s75 → map mo_s88
  60. NFKB1@Nucleus map → map NFKB1@Nucleus map
  61. gFOS@Nucleus map → map rFOS@Nucleus map
  62. gPXN@Nucleus map → map rPXN@Nucleus map