Identifiers
HUGO:JUP
References
em_emtc_emtc_re1625( EMT Senescence ):
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.
http://d-scholarship.pitt.edu/18634/1/Zimmerman_ETD-2013.pdf
c-MYC activity was able to increase Ptp4a3 gene expression in a fibroblast cell culture model.
Tumors from the Ptp4a3-null mice had elevated levels of both IGF1R?? and c-MYC compared to tumors replete with PTP4A3.
Ptp4a3-null cells displayed less migration compared to wildtype cells and loss of VEGF-induced phosphorylation of SRC protein.
Reduced migration and SRC activation were also observed when human endothelial cells were treated with a small molecule inhibitor of PTP4A3.