Protein MMP2* map

Identifiers
HUGO:MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
HUGO:MMP2, HGNC:7166, ENTREZ:4313, GENECARDS:GC16P055478, P08253

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

MMP2*@default

References
mo_re159:( motility  map ) PMID:19930715 PMID:26597054 PMID:27572739 PMID:27510662
mo_re160:( motility  map ) PMID:19930715 PMID:26597054 PMID:27510662

MMP2*@Extracellular space

References
em_emtc_emtc_re1586( EMT Senescence  map ):
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.
em_emtc_emtc_re228( EMT Senescence  map ):
PMID:21900405
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP

Modifications:
In compartment: Extracellular space
  1. MMP2*@Extracellular space map
In compartment: default
  1. MMP2*@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MMP2@Extracellular space map → map MMP2*@Extracellular space map
    2. MMP2@default map → map MMP2*@default map
    3. MMP2*@default map → map Invasion@default map
    As Catalyser:
    1. Laminin5*@Extracellular space map → map Truncated Laminin5*@Extracellular space map
    2. Collagen4*@Extracellular space map → map Truncated Collagen4*@Extracellular space map
    3. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map → map TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map