Protein MMP2 map

Identifiers
matrix metallopeptidase 2
HUGO:MMP2 hgnc_id:HGNC:7166 HGNC:7166 ENTREZ:4313 UNIPROT:P08253
HUGO:MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
HUGO:MMP2, HGNC:7166, ENTREZ:4313, GENECARDS:GC16P055478, P08253

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
CASCADE:TNF
CASCADE:INTEGRIN
PMID:11112697
TNF-?? upregulates MT1-MMP (MMP14) mRNA in organ-cultured human skin and dermal fibroblasts in a collagen environment
NF-??B inhibitor, SN50, blocks TNF-?? and collagen mediated MT1-MMP expression and pro-MMP-2 activation.
PMID:1323219
MMP2 and TIMP2 are axpressed by CAFS
 MACROPHAGE  map
PMID:22880008
Classical activation of macrophages derived in vitro from un-fractionated CD16(+/-) or negatively-selected CD16(-) macrophages up-regulated MMP-1, -3, -7, -10, -12, -14 and -25 and decreased TIMP-3 steady-state mRNA levels.
By contrast, alternative activation decreased MMP-2, -8 and -19 but increased MMP -11, -12, -25 and TIMP-3 steady-state mRNA levels. Up-regulation of MMPs during classical activation depended on mitogen activated protein kinases, phosphoinositide-3-kinase and inhibitor of ??B kinase-2. Effects of interferon?? depended on janus kinase-2.
PMID:24526468
Pancreatic cancer cells (Panc-1, MiaPaca-2, HPAF, and
ASPC, data pooled) upregulated MMP2 expression in
macrophages .
PMID:18633355
MDSC isolated from murine tumours express higher levels of various MMPs (MMP2, MMP9, MMP13 and MMP14 than MDSC from healthy mice

MMP2@default

References
mo_re157:( motility  map ) PMID:19930715 PMID:26597054 PMID:27572739 PMID:27510662

MMP2@Extracellular space

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
em_emtc_emtc_re1586( EMT Senescence  map ):
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.

Modifications:
In compartment: Cytosol
  1. MMP2@Cytosol map
In compartment: Extracellular space
  1. MMP2@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MMP2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. MMP2@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MMP2@Cytosol map → map MMP2@Cytosol map
    2. MMP2@Cytosol map → map MMPs*@Cytosol map
    3. MMP2@Extracellular space map → map MMP2*@Extracellular space map
    4. MMP2@Cytosol map → map MMP2@Extracellular space map
    5. rMMP2@Nucleus map → map MMP2@Cytosol map
    6. MMP2@INNATE_IMMUNE_CELL_Cytosol map → map MATRIX_REMODELLING@default map
    7. rMMP2@Nucleus map → map MMP2@Cytosol map
    8. MMP2@Cytosol map → map MMP2@default map
    9. MMP2@default map → map MMP2*@default map
    As Catalyser: