→ rTIMP2@Nucleus References
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.