Protein BCL3 map

Identifiers
HUGO:BCL3

Maps_Modules
MODULE:MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS

References
PMID:15465827
BCL3 inhibits expression of IL1A, IL1B,TNF and positively regulates
IL-10 expression. BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
PMID:12907458
Bcl-3??? ???interacted with NF-??B p50,
both Bcl-3??? ???and p50??? ???were recruited to the TNF promoter,
BCL3??? ??? and??? ???p50??? ???NFkB recruitment to??? ???TNF ???promoter
prevents binding of??? ???p65/p50??? ???NFkB??? ???heterodimers
to??? ???TNF promotor and suppresses??? ???TNF ???expression
downstream of??? ???IL10.

BCL3@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. BCL3@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. BCL3:​HDAC1@Cytosol map
  2. BCL3:​NFKB1_p50*|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. BCL3@Cytosol map + HDAC1@Cytosol map → map BCL3:​HDAC1@Cytosol map
  2. BCL3@Cytosol map + NFKB1_p50*|​hm2@Cytosol map → map BCL3:​NFKB1_p50*|​hm2@Cytosol map
  3. rBCL3@Cytosol map → map BCL3@Cytosol map
As Catalyser:
  1. gTNF@Cytosol map → map rTNF@Cytosol map
  2. gIL10@Cytosol map → map rIL10@Cytosol map
  3. gIL1A@Cytosol map → map rIL1A@Cytosol map
  4. gIL1B@Cytosol map → map rIL1B@Cytosol map
  5. RELA@Cytosol map + NFKB1_p50*@Cytosol map → map NFKB1_p50*:​RELA|​pho@Cytosol map