Protein PPP1C* map

Identifiers
protein phosphatase 1 catalytic subunit alpha
HUGO:PPP1CA hgnc_id:HGNC:9281 HGNC:9281 ENTREZ:5499 UNIPROT:P62136
protein phosphatase 1 catalytic subunit beta
HUGO:PPP1CB hgnc_id:HGNC:9282 HGNC:9282 ENTREZ:5500 UNIPROT:P62140
protein phosphatase 1 catalytic subunit gamma
HUGO:PPP1CC hgnc_id:HGNC:9283 HGNC:9283 ENTREZ:5501 UNIPROT:P36873
protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1A, "protein phosphatase 1, catalytic subunit, alpha isoform"
HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136
protein phosphatase 1, catalytic subunit, beta isozyme
HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140
protein phosphatase 1, catalytic subunit, gamma isozyme
HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873
HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 GENECARDS:PPP1CA REACTOME:61996 KEGG:5499 ATLASONC:GC_PPP1CA WIKI:PPP1CA
HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140 GENECARDS:PPP1CB REACTOME:62004 KEGG:5500 ATLASONC:GC_PPP1CB WIKI:PPP1CB
HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873 GENECARDS:PPP1CC REACTOME:62014 KEGG:5501 ATLASONC:GC_PPP1CC WIKI:PPP1CC

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / NECROPTOSIS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
catalytic subunit of phosphatase PP1A, PP1c
3 genes encode 3 isoforms
PMID:20399103

PPP1C*@Cytosol

References
em_emtc_emtc_re1016( EMT Senescence  map ):
PMID:17318175
PPP1 regulates assembly and function of the CTNNB1 degradation complex.
PPP1 reverses CSNK1 (casein kinase 1) - mediated phosphorylation of AXIN1.
This dephosphorylation allows CTNNB1 to escape the degradation complex of AXIN1 and APC.

Modifications:
In compartment: Cytosol
  1. PPP1C*@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. PPP1C*:​PPP1R*@Cytoplasm map
  2. APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  3. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
In compartment: Cytosol
  1. M20*:​PPP1C*:​PPP1R12A|​pho@Cytosol map
  2. (M20*:​PPP1C*:​PPP1R12A)|​active@Cytosol map
In compartment: Mitochondrial inner membrane
  1. BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
  2. BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. (M20*:​PPP1C*:​PPP1R12A)|​active@Cytosol map → map M20*:​PPP1C*:​PPP1R12A|​pho@Cytosol map
  2. PPP1C*@Cytosol map → map PPP1CA@Cytosol map
  3. PPP1C*@Cytosol map → map PPP1CB@Cytosol map
  4. PPP1C*@Cytosol map → map PPP1CC@Cytosol map
  5. BAD|​S91_unk|​active@Cytosol map + GCK@Cytosol map + WASF1@Cytosol map + PRKAC*@Cytosol map + PPP1C*@Cytosol map → map BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
  6. BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map → map BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
  7. BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map → map BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
  8. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map + PPP1C*:​PPP1R*@Cytoplasm map → map AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  9. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map → map APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  10. APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map → map GSK3*@Cytoplasm map + AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map + PPP1C*:​PPP1R*@Cytoplasm map
As Catalyser:
  1. ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*|​pho@Cytosol map → map ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*@Cytosol map
  2. (APC|​pho:​AXIN1|​pho)|​active@Cytosol map → map APC:​AXIN1@Cytosol map
  3. glucose@Cytosol map + ATP@Cytosol map → map glucose-6P@Cytosol map + ADP@Cytosol map