Protein WASF1 map

Identifiers
WAS protein family, member 1
HUGO:WASF1 HGNC:12732 ENTREZ:8936 UNIPROT:Q92558

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / NECROPTOSIS  map

WASF1@Cytosol

References
em_emtc_emtc_re802( EMT Senescence  map ):
Rac1 stimulates actin polymerization by activation of WAS protein family (WASF1 and WASF2)
PMID:16212495
PMID:9843499
PMID:16702231
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin
em_emtc_emtc_re791( EMT Senescence  map ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:14749719
PAK1 phosphorylates and activates ARP2_3 complex.

Modifications:
In compartment: Cytosol
  1. WASF1@Cytosol map
Participates in complexes:
In compartment: Mitochondrial inner membrane
  1. BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
  2. BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. WASF1@Cytosol map → map WASF1@Cytosol map
  2. BAD|​S91_unk|​active@Cytosol map + GCK@Cytosol map + WASF1@Cytosol map + PRKAC*@Cytosol map + PPP1C*@Cytosol map → map BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
  3. BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map → map BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
  4. BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map → map BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial inner membrane map
As Catalyser:
  1. ARP2_3*@Cytosol map → map ARP2_3*@Cytosol map
  2. glucose@Cytosol map + ATP@Cytosol map → map glucose-6P@Cytosol map + ADP@Cytosol map