Identifiers
peptidylprolyl isomerase D
HUGO:PPID HGNC:9257 ENTREZ:5481 UNIPROT:Q08752
synonyms:cyclophilin D, cypD
"peptidylprolyl isomerase D (cyclophilin D)"

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / MITOCHONDRIAL_PERMEABILITY_TRANSITION 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 

References
peptidylprolyl isomerase D
PMID:20823910
PMID:18309324
Mitochondrial chaperone cyclophilin D (CYPD) enhances PTP opening.
PMID:20080742

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 

References
su_mpk1_mpk1_re120( Survival  ):
We postulate a model in which ERK activation inhibits GSK3 activity (by phosphorylation) its association to CYPD and CYPD phosphorylation (by GSK3) leading to PTP desensitisation.
PMID:20080742

1. PPID@Mitochondria
2. PPID|​pho@Mitochondria

1. (ANT*:​CK*:​HK*:​PPID:​TSPO:​VDAC*)|​active@Mitochondrial inner membrane

1. (ANT*:​CK*:​HK*:​PPID:​TSPO:​VDAC*)|​active@Mitochondrial inner membrane → (ANT*:​CK*:​HK*:​PPID:​TSPO:​VDAC*)|​active@Mitochondrial inner membrane
2. (ANT*:​CK*:​HK*:​PPID:​TSPO:​VDAC*)|​active@Mitochondrial inner membrane → MOMP@Mitochondrial inner membrane
3. VDAC*@Mitochondria + ANT*@Mitochondrial inner membrane + PPID@Mitochondria + CK*@Mitochondria + HK*@Cytosol + TSPO@Mitochondria → (ANT*:​CK*:​HK*:​PPID:​TSPO:​VDAC*)|​active@Mitochondrial inner membrane
4. (ANT*:​CK*:​HK*:​PPID:​TSPO:​VDAC*)|​active@Mitochondrial inner membrane → ROS Production@Cytosol
5. PPID@Mitochondria → PPID|​pho@Mitochondria

1. cleaved~AIFM1*@Mitochondrial inner membrane → cleaved~AIFM1*@Cytosol