Protein CDK4_6* map

Identifiers
CDK4_6*
cyclin-dependent kinase 4
HUGO:CDK4, HGNC:1773, ENTREZ:1019, GENECARDS:GC12M058142, UNIPROT:P11802??
cyclin-dependent kinase 6
HUGO:CDK6, HGNC:1777, ENTREZ:1021, GENECARDS:GC07M092234, UNIPROT:Q00534????
HUGO:CDK4, HGNC:1773, ENTREZ:1019, UNIPROT:P11802
HUGO:CDK6, HGNC:1777, ENTREZ:1021, UNIPROT:Q00534
HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4
HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G1_CC_PHASE  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:23140366
PMID:17055429
p16 and p15 activates the pRB tumor supressor by inhibiting the cyclin dependent kinase CDK4 and CDK6, which promotes proliferation. The inhibition of CDK4 and CDK6 ability to phosphorylate Rb, maintains Rb-family protein in a hypophosphorylated state which promotes G1 cell cycle arrest
PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
PMID:18414028
PMID:19887899

CDK4_6*@Cytosol

References
em_emtc_emtc_re256( EMT Senescence  map ):
PMID:23140366
PMID:17055429
p16 and p15 activates the pRB tumor supressor by inhibiting the cyclin dependent kinase CDK4 and CDK6, which promotes proliferation. The inhibition of CDK4 and CDK6 ability to phosphorylate Rb, maintains Rb-family protein in a hypophosphorylated state which promotes G1 cell cycle arrest

CDK4_6*@Cytoplasm

References
s_akt1_re98:( Survival  map ) PMID:19887899

Modifications:
In compartment: Cytoplasm
  1. CDK4_6*@Cytoplasm map
In compartment: Cytosol
  1. CDK4_6*@Cytosol map
In compartment: Nucleus
  1. CDK4_6*@Nucleus map
Participates in complexes:
In compartment: Cytoplasm
  1. CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm map
  2. CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm map
In compartment: Cytosol
  1. CDK4_6*:​CyclinD1*@Cytosol map
  2. CDK4_6*:​p15INK4B*@Cytosol map
  3. CDK4_6*:​p16INK4A*@Cytosol map
  4. CDK4_6*:​CyclinD1*:​p21CIP1*@Cytosol map
  5. CDK4_6*:​CyclinD1*:​p27KIP1*@Cytosol map
In compartment: Nucleus
  1. CDK4_6*:​INK4*@Nucleus map
  2. CDK4_6*:​CyclinD*@Nucleus map
  3. CDK4_6*:​CyclinD*|​pho@Nucleus map
  4. CDK4_6*|​Y14_pho:​CyclinD*@Nucleus map
  5. CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@Nucleus map
  6. (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus map
  7. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. CyclinD*@Nucleus map + CDK4_6*@Nucleus map → map CDK4_6*:​CyclinD*@Nucleus map
  2. CDK4_6*@Nucleus map + INK4*@Nucleus map → map CDK4_6*:​INK4*@Nucleus map
  3. (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus map + CIP1_KIP1*@Nucleus map → map (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus map
  4. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus map → map CIP1_KIP1*@Nucleus map + (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus map
  5. CDK4_6*:​INK4*@Nucleus map → map INK4*@Nucleus map + CDK4_6*@Nucleus map
  6. CDK4_6*:​CyclinD*@Nucleus map → map CDK4_6*|​Y14_pho:​CyclinD*@Nucleus map
  7. CDK4_6*|​Y14_pho:​CyclinD*@Nucleus map → map CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@Nucleus map
  8. CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@Nucleus map → map (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus map
  9. CDK4_6*:​CyclinD*@Nucleus map → map CDK4_6*:​CyclinD*|​pho@Nucleus map
  10. CDK4_6*:​CyclinD*|​pho@Nucleus map → map CyclinD*|​pho@Nucleus map + CDK4_6*@Nucleus map
  11. CDK4_6*@Cytosol map → map CDK4@Cytosol map
  12. CDK4_6*@Cytosol map → map CDK6@Cytosol map
  13. CDK4_6*:​CyclinD1*@Cytosol map → map Early to mid-G1 phase@Cytosol map
  14. CDK4_6*@Cytosol map + p15INK4B*@Cytosol map → map CDK4_6*:​p15INK4B*@Cytosol map
  15. CDK4_6*@Cytosol map + p16INK4A*@Cytosol map → map CDK4_6*:​p16INK4A*@Cytosol map
  16. CDK4_6*@Cytosol map + CyclinD1*@Cytosol map → map CDK4_6*:​CyclinD1*@Cytosol map
  17. p21CIP1*@Cytosol map + CDK4_6*:​CyclinD1*@Cytosol map → map CDK4_6*:​CyclinD1*:​p21CIP1*@Cytosol map
  18. CDK4_6*:​CyclinD1*@Cytosol map + p27KIP1*@Cytosol map → map CDK4_6*:​CyclinD1*:​p27KIP1*@Cytosol map
  19. CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm map → map su_akt1_s_akt1_s736
  20. CDK4_6*@Cytoplasm map + p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map + CyclinD*@Cytoplasm map → map CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm map
  21. CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map → map CyclinD*|​T286_pho@Nucleus map + p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map + CDK4_6*@Nucleus map
  22. p21CIP1*|​pho|​pho@Nucleus map + CyclinD*|​T286_pho@Nucleus map + CDK4_6*@Nucleus map → map CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus map
  23. CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm map → map su_akt1_s_akt2_s120
  24. rCyclinD*@Nucleus map → map CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm map
As Catalyser:
  1. G1 phase@Nucleus map → map S phase@Nucleus map
  2. E2F1:​RB1@Nucleus map → map E2F1:​RB1|​pho@Nucleus map
  3. E2F4_5*:​p107*@Nucleus map → map E2F4_5*:​p107*|​pho@Nucleus map
  4. pRB*@Cytosol map → map pRB*|​pho@Cytosol map