Protein p16INK4A* map

Identifiers
cyclin-dependent kinase inhibitor 2A
HUGO:CDKN2A, HGNC:1787, ENTREZ:1029, GENECARDS:GC09M021957, UNIPROT:P42771????

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map

References
PMID:23140366
PMID:17055429
p16 and p15 activates the pRB tumor supressor by inhibiting the cyclin dependent kinase CDK4 and CDK6, which promotes proliferation. The inhibition of CDK4 and CDK6 ability to phosphorylate Rb, maintains Rb-family protein in a hypophosphorylated state which promotes G1 cell cycle arrest
PMID:26592237
P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and
promotes cancer metastasis

p16INK4A*@Cytosol

References
em_emtc_emtc_re257( EMT Senescence  map ):
PMID:23140366
PMID:17055429
p16 and p15 activates the pRB tumor supressor by inhibiting the cyclin dependent kinase CDK4 and CDK6, which promotes proliferation. The inhibition of CDK4 and CDK6 ability to phosphorylate Rb, maintains Rb-family protein in a hypophosphorylated state which promotes G1 cell cycle arrest
em_re1637( EMT Senescence  map ):
PMID:26592237
P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and
promotes cancer metastasis

Modifications:
In compartment: Cytosol
  1. p16INK4A*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CDK4_6*:​p16INK4A*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rp16INK4A*@Nucleus map → map p16INK4A*@Cytosol map
  2. CDK4_6*@Cytosol map + p16INK4A*@Cytosol map → map CDK4_6*:​p16INK4A*@Cytosol map
  3. p16INK4A*@Cytosol map → map Metastasis@Cytosol map
As Catalyser: