Protein CDK4 map

Identifiers
cyclin-dependent kinase 4
HUGO:CDK4, HGNC:1773, ENTREZ:1019, GENECARDS:GC12M058142, UNIPROT:P11802??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map

CDK4@Cytosol

References
em_emtc_emtc_re1276( EMT Senescence  map ):
PMID:10197981
PMID:12193595
PMID:16156666
Erk kinases phosphorylate Smad2 and Smad3 at specific sites in the region linking the DNA-binding domain and the transcriptional activation domain.
These sites are separate from the TGFB receptor phosphorylation sites that activate Smad nuclear translocation.
Feedback loop: TGFB activates Ras/Raf/Mek/Erk signaling (PMID:17673906) and Erk reduces TGFB/Smads transcriptional activity.
PMID:15241418
Feedback loop
CDK phosphorylation of Smad3 on Thr8/Thr179/Ser213 inhibits its transcriptional activity and antiproliferative function.
Because cancer cells often contain high levels of CDK activity, diminishing Smad3 activity by CDK phosphorylation may contribute to tumorigenesis and TGFB- resistance in
cancers.

Modifications:
In compartment: Cytosol
  1. CDK4@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CDK4_6*@Cytosol map → map CDK4@Cytosol map
    2. CDK2_4*@Cytosol map → map CDK4@Cytosol map
    3. rCDK4@Nucleus map → map CDK4@Cytosol map
    As Catalyser:
    1. SMAD3|​S423_pho|​S425_pho@Cytosol map → map SMAD3|​T179_pho|​S204_pho|​S208_pho|​S213_pho|​S423_pho|​S425_pho@Cytosol map