Identifiers
HUGO:RB1
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
References
PMID:23140366
PMID:17055429
p16 and p15 activates the pRB tumor supressor by inhibiting the cyclin dependent kinase CDK4 and CDK6, which promotes proliferation. The inhibition of CDK4 and CDK6 ability to phosphorylate Rb, maintains Rb-family protein in a hypophosphorylated state which promotes G1 cell cycle arrest
References
em_emtc_emtc_re271( EMT Senescence ):
PMID:15082531
Degradation of c-Myb protein by Wnt-1 signal via the pathway involving TAK1, HIPK2, and NLK leads to G1 cell cycle arrest.
PMID:23140366
p16INK4a activates the pRB tumor suppressor, which silences certain proproliferative genes(E2F) by heterochromatinization, thereby instituting a stringent arrest of cell proliferation
PMID:19440234
p21 suppresses E2F1-dependent Wnt4 expression, thereby controlling cellular growth.
em_re1624( EMT Senescence ):
PMID:17055429
p16 and p15 activates the pRB tumor supressor by inhibiting the cyclin dependent kinase CDK4 and CDK6, which promotes proliferation. The inhibition of CDK4 and CDK6 ability to phosphorylate Rb, maintains Rb-family protein in a hypophosphorylated state which promotes G1 cell cycle arrest
References
em_re1624( EMT Senescence ):
PMID:23140366
PMID:17055429
p16 and p15 activates the pRB tumor supressor by inhibiting the cyclin dependent kinase CDK4 and CDK6, which promotes proliferation. The inhibition of CDK4 and CDK6 ability to phosphorylate Rb, maintains Rb-family protein in a hypophosphorylated state which promotes G1 cell cycle arrest