Reaction known_transition_omitted em_emtc_emtc_re271 map

Late G1 phase@Cytosol map → S phase@Cytosol map

Reaction regulators:
Catalysis
  1. MYB@Cytosol map
Inhibition
  1. pRB*@Cytosol map
  2. p21CIP1*@Cytosol map


References
PMID:15082531
Degradation of c-Myb protein by Wnt-1 signal via the pathway involving TAK1, HIPK2, and NLK leads to G1 cell cycle arrest.
PMID:23140366
p16INK4a activates the pRB tumor suppressor, which silences certain proproliferative genes(E2F) by heterochromatinization, thereby instituting a stringent arrest of cell proliferation
PMID:19440234
p21 suppresses E2F1-dependent Wnt4 expression, thereby controlling cellular growth.