Protein NLK map

Identifiers
nemo-like kinase
"nemo like kinase"
HUGO:NLK HGNC:29858 ENTREZ:51701 UNIPROT:Q9UBE8 GENECARDS:NLK KEGG:2821 ATLASONC:GC_NLK WIKI:NLK

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:15082531
The activation of MP3K7(TAK1) by TAB1 activates NLK. the TAK1???NLK MAPK pathway regulates Wnt signaling by phosphorylating TCF in mammalian cells.
The TAB1 protein is a specific partner of TAK1 and promotes TAK1 autophosphorylation.
Coexpression of TAK1 and TAB1 in mammalian cells activate HIPK2, that activate NLK. THe coexpression of NLK and HIPK2 induces the degradation of the c-Myb protein.
Degradation of c-Myb protein by Wnt-1 signal via the pathway involving TAK1, HIPK2, and NLK leads to G1 arrest.
PMID:10391247
TAK1 activation stimulates NLK activity and downregulates transcriptional activation mediated by beta-catenin and TCF.

NLK@Cytoplasm

References
s_wca3_re27:( Survival  map ) PMID:21118996

NLK|​hm2@Cytoplasm

References
s_wca3_re27:( Survival  map ) PMID:21118996
s_wca3_re28( Survival  map ):
PMID:21118996 PMID:15082531
Auto-phosphorylation
HMC:EVADING_GROWTH_SUPPRESSORS
HIPK2 may induce autophoshorylationMaps_Modules_end

NLK|​T286_pho|​hm2|​active@Cytoplasm

References
s_wca3_re28( Survival  map ):
PMID:21118996 PMID:15082531
Auto-phosphorylation
HMC:EVADING_GROWTH_SUPPRESSORS
HIPK2 may induce autophoshorylationMaps_Modules_end

NLK|​T286_pho|​hm2|​active@Nucleus

References
s_wca3_re29:( Survival  map ) PMID:21118996
s_wca3_re25:( Survival  map ) PMID:20194509

Modifications:
In compartment: Cytoplasm
  1. NLK@Cytoplasm map
  2. NLK|​hm2@Cytoplasm map
  3. NLK|​T286_pho|​hm2|​active@Cytoplasm map
In compartment: Nucleus
  1. NLK@Nucleus map
  2. NLK|​T286_pho|​hm2|​active@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. NLK@Nucleus map → map NLK@Nucleus map
  2. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map + NLK|​T286_pho|​hm2|​active@Nucleus map + TAB2@Nucleus map → map NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
  3. NLK@Cytoplasm map → map NLK|​hm2@Cytoplasm map
  4. NLK|​hm2@Cytoplasm map → map NLK|​T286_pho|​hm2|​active@Cytoplasm map
  5. NLK|​T286_pho|​hm2|​active@Cytoplasm map → map NLK|​T286_pho|​hm2|​active@Nucleus map
As Catalyser:
  1. MYB@Cytosol map → map degraded
  2. LEF_TCF*@Nucleus map → map LEF_TCF*|​S166_pho|​T155_pho@Nucleus map