Protein TAB1 map

Identifiers
TGF-beta activated kinase 1/MAP3K7 binding protein 1
MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1"
HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:15082531
The activation of MP3K7(TAK1) by TAB1 activates NLK. the TAK1???NLK MAPK pathway regulates Wnt signaling by phosphorylating TCF in mammalian cells.
The TAB1 protein is a specific partner of TAK1 and promotes TAK1 autophosphorylation.
Coexpression of TAK1 and TAB1 in mammalian cells activate HIPK2, that activate NLK. THe coexpression of NLK and HIPK2 induces the degradation of the c-Myb protein.
Degradation of c-Myb protein by Wnt-1 signal via the pathway involving TAK1, HIPK2, and NLK leads to G1 arrest.
PMID:10391247
TAK1 activation stimulates NLK activity and downregulates transcriptional activation mediated by beta-catenin and TCF.

TAB1@Cytoplasm

References
s_wca3_re30:( Survival  map ) PMID:20538596

Modifications:
In compartment: Cytoplasm
  1. TAB1@Cytoplasm map
In compartment: Cytosol
  1. TAB1@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. TAB1:​TAK1*@Cytoplasm map
  2. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm map
  3. TAB1:​TAB2:​TAK1*|​emp@Cytoplasm map
  4. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  5. RCAN*|​S94_pho|​S136_pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  6. FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm map
In compartment: Nucleus
  1. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
  2. NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. MAP3K7@Cytosol map + TAB1@Cytosol map → map em_s2334
  2. FZD*:​ROR2:​WNT1_3*@Cytoplasm map → map TAB1:​TAK1*@Cytoplasm map
  3. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map + NLK|​T286_pho|​hm2|​active@Nucleus map + TAB2@Nucleus map → map NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
  4. TAK1*@Cytoplasm map + TAB1@Cytoplasm map → map TAB1:​TAK1*@Cytoplasm map
  5. TAB1:​TAK1*@Cytoplasm map → map TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm map
  6. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm map → map TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
  7. TGF-_beta_ pathway@Extracellular space map → map TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  8. RCAN*|​T192_pho@Cytoplasm map + TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map → map RCAN*|​S94_pho|​S136_pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  9. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map → map TAB1:​TAB2:​TAK1*|​emp@Cytoplasm map
  10. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map + FZD*:​ROR2|​pho:​WNT3@Cytoplasm map → map FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm map
  11. FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
As Catalyser:
  1. LEF_TCF*@Nucleus map → map LEF_TCF*|​S166_pho|​T155_pho@Nucleus map
  2. TAB1:​TAK1*@Cytoplasm map → map TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm map
  3. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map → map Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  4. FZD*:​ROR2:​WNT3@Cytoplasm map → map FZD*:​ROR2|​pho:​WNT3@Cytoplasm map