Protein cleaved~BECN1* map

Identifiers
beclin 1, autophagy related
HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
PMID:23377657

cleaved~BECN1*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re651( Regulated Cell Death  map ):
in vitro by CASP3, CASP7, CASP8
in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavage
in Ba/F3 upon doxorubicin or etoposide or anti-FasPMID:23377657
rc_re652( Regulated Cell Death  map ):
in Ba/F3 upon IL3 deprivation (cell fractionation)
in Hela expressing the tagged C-terminal cleavage product of BECN1 (microscopy)PMID:23377657

cleaved~BECN1*@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re652( Regulated Cell Death  map ):
in Ba/F3 upon IL3 deprivation (cell fractionation)
in Hela expressing the tagged C-terminal cleavage product of BECN1 (microscopy)PMID:23377657
rc_re8( Regulated Cell Death  map ):
in Ba/F3 cells, stable expression of the C-terminal cleavage product of BECN1 sensitizes cells to IL3-deprivation induced apoptosis
in vitro, incubation of isolated mitochondria with recombinant BECN1 C-terminal cleavage product triggers release of Omi/HtrA2 and cytochrome c
PMID:11832478
in vitro CASP2 unlike CASP8 induce release of CYCS , DIABLO and AIF form purified mitochondria from Hela cellsPMID: PMID:23242420
calpain-mediated Bax and Atg5 cleavage resulted in the collapse of the mitochondrial membrane potential and cytochrome c release

Modifications:
In compartment: Cytosol
  1. cleaved~BECN1*@Cytosol map
In compartment: Mitochondrial inner membrane
  1. cleaved~BECN1*@Mitochondrial inner membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. BECN1|​T119_unk@Cytosol map → map cleaved~BECN1*@Cytosol map
    2. cleaved~BECN1*@Cytosol map → map cleaved~BECN1*@Mitochondrial inner membrane map
    As Catalyser:
    1. Mitochondria outer~membrane integrity@Mitochondrial inner membrane map → map MOMP@Mitochondrial inner membrane map