Identifiers
beclin 1, autophagy related
HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 

References
PMID:23377657
PMID:17446862
PMID:27754749

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 

References
rc_re1803( Regulated Cell Death  ):
PMID:17891140
PMID:17106237
PMID:22885520
PMID:18612260
rc_re410( Regulated Cell Death  ):
PMID:9765397
PMID:10604474
PMID:16179260
rc_re1032( Regulated Cell Death  ):
PMID:19180116
PMID:11323415
in HEK293
in vitro
DAPK1 mediated phosphorylation of BECN1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
rc_re1034:( Regulated Cell Death  ) reactionType:is.a
rc_re1388( Regulated Cell Death  ):
PMID:17446862
rc_re1787( Regulated Cell Death  ):
PMID:23030059
PMID:23974797
PMID:21358617

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 

References
rc_re1032( Regulated Cell Death  ):
PMID:19180116
PMID:11323415
in HEK293
in vitro
DAPK1 mediated phosphorylation of BECN1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
rc_re1033:( Regulated Cell Death  ) reactionType:is.a

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 

References
rc_re1033:( Regulated Cell Death  ) reactionType:is.a
rc_re651( Regulated Cell Death  ):
in vitro by CASP3, CASP7, CASP8
in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavage
in Ba/F3 upon doxorubicin or etoposide or anti-FasPMID:23377657

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / RCD_GENES 

References
rc_re1787( Regulated Cell Death  ):
PMID:23030059
PMID:23974797
PMID:21358617
rc_re1830( Regulated Cell Death  ):
PMID:17446862
PMID:17106237
PMID:22885520
PMID:18612260
rc_re1762( Regulated Cell Death  ):
PMID:23725295

1. BECN1@Cytosol
2. BECN1|​ubi@Cytosol
3. BECN1|​T119_pho@Cytosol
4. BECN1|​T119_unk@Cytosol

1. ATG14:​BECN1|​ubi:​PIK3C3:​PIK3R4:​UVRAG@Autopagosome

1. BCL2:​BECN1:​UVRAG@Cytosol
2. BCL2-XL*:​BECN1:​UVRAG@Cytosol

1. BECN1@Cytosol → BECN1|​T119_pho@Cytosol
2. BECN1|​T119_pho@Cytosol → BECN1|​T119_unk@Cytosol
3. BECN1@Cytosol → BECN1|​T119_unk@Cytosol
4. BCL2-XL*@Cytosol + BECN1@Cytosol + UVRAG@Cytosol → BCL2-XL*:​BECN1:​UVRAG@Cytosol
5. BECN1|​ubi@Cytosol + PIK3C3@Cytosol + ATG14@Cytosol + UVRAG@Cytosol + PIK3R4@Cytosol → ATG14:​BECN1|​ubi:​PIK3C3:​PIK3R4:​UVRAG@Autopagosome
6. BECN1@Cytosol → BECN1|​ubi@Cytosol
7. BECN1|​ubi@Cytosol → BECN1@Cytosol
8. BCL2:​BECN1:​UVRAG@Cytosol → BCL2@Cytosol + BECN1@Cytosol + UVRAG@Cytosol
9. BCL2-XL*:​BECN1:​UVRAG@Cytosol → BCL2-XL*@Cytosol + BECN1|​ubi@Cytosol + UVRAG@Cytosol
10. rBECN1@Nucleus → BECN1@Cytosol
11. BECN1@Cytosol + BCL2@Cytosol + UVRAG@Cytosol → BCL2:​BECN1:​UVRAG@Cytosol
12. BECN1|​T119_unk@Cytosol → cleaved~BECN1*@Cytosol

1. PIP2@Autopagosome → PIP3*@Autopagosome
2. Autophagosome initiation@Autopagosome → Autophagosome formation@Autopagosome