Identifiers
caspase 2, apoptosis-related cysteine peptidase
HUGO:CASP2 HGNC:1503 ENTREZ:835 UNIPROT:P42575
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
References
rc_re1152( Regulated Cell Death ):
PMID:11399776
in vitro by CASP3 and to a lesser extent by CASP7
PMID:15073321
by LRDD and CRADD
rc_re508( Regulated Cell Death ):
PMID:9727492
in vitro cleavage of BID by CASP8 and GZMB, BID poor substrate for CASP3
in Jurkat cleavage of BID by CASP8 upon Fas stimulation
in Hela exposed to TNF+CHX cleavage of BID by CASP8
PMID:10805722
in vitro cleavage of in vitro translated BID by purified granzyme B
in Jurkat cells exposed to GZMB+adenovirus, BID cleavage occurs independently of caspases (zVAD-fmk)
PMID:11085743
in Jurkat cells exposed to GZMB+perforin, Bcl2 over-expression mediated cell protection is abrogated by over-over-expression of BID (wt or CASP8-uncleavable mutant) but of D75 (GZMB in vitro cleavage site) mutant
PMID:11085742
in Jurkat cells exposed to GZMB+adenovirus+zVAD-fmk, BID is cleaved and localizes to mitochondria
PMID:10364179
cleavage of BID by CASP8 and CASP3
PMID:11832478
in vitro by CASP2
rc_re1234( Regulated Cell Death ):
PMID:20125124
by HTRA2
PMID:10521396
by CASP8
PMID:19935698
by CASP2
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
References
rc_re1402( Regulated Cell Death ):
PMID:19203584
involvment of CRADD is doubtful