Protein PLK1 map

Identifiers
polo-like kinase 1
HUGO:PLK1, HGNC:9077, ENTREZ:5347, UNIPROT:P53350, GENECARDS:PLK1
polo-like kinase 1 (Drosophila)
HUGO:PLK1, HGNC:9077, ENTREZ:5347, UNIPROT:P53350

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map

References
PMID:8127874
For Fanconi anemia pathway
PMID:19686080, PMID:19622404, PMID:18931676
FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint.
Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156

PLK1@Nucleus

References
te_re10:( Telomere Maintenance  map ) PMID:18625707, PMID:22634377
te_re25:( Telomere Maintenance  map ) PMID:21818122, PMID:22433952

PLK1|​pho|​active@Nucleus

References
ce_re194( Cell Cycle DNA Repair  map ):
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
ce_re313( Cell Cycle DNA Repair  map ):
Activation by PLK phosphorylation at S191, S198
Activation by CDC2 phosphorylation at S214
PMID:17596790
ce_re449:( Cell Cycle DNA Repair  map ) PMID:11073952

Modifications:
In compartment: Nucleus
  1. PLK1@Nucleus map
  2. PLK1|​pho|​active@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PLK1@Nucleus map → map PLK1|​pho|​active@Nucleus map
    As Catalyser:
    1. FANCM@Nucleus map → map FANCM|​pho@Nucleus map
    2. WEE1|​CHEK1site_pho@Nucleus map → map WEE1|​pho@Nucleus map
    3. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@Nucleus map
    4. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@Nucleus map
    5. CDC25B@Nucleus map → map CDC25B|​S353_pho|​active@Nucleus map
    6. CDC25C@Nucleus map → map CDC25C|​S191_pho|​S198_pho|​S214_pho|​active@Nucleus map
    7. EMI1*@Nucleus map → map EMI1*|​pho@Nucleus map
    8. MYC@Nucleus map + MIZ1*@Nucleus map + PKMYT1@Nucleus map → map ce_s2499
    9. STAG*@Nucleus map → map STAG*|​pho@Nucleus map
    10. SCC1*@Nucleus map → map SCC1*|​PLK1-dep._pho@Nucleus map
    11. TERF1|​T344_pho|​hm2@Nucleus map → map TERF1|​S435_pho|​T344_pho|​hm2@Nucleus map
    12. TNKS@Nucleus map → map TNKS|​pho@Nucleus map