Reaction state_transition rc_re498 map

Caspase9*|​S196_unk|​S144_unk|​Y153_unk@Cytosol map → Caspase9*|​S196_unk|​T125_pho|​S144_unk|​Y153_unk@Cytosol map

Reaction regulators:
Catalysis
  1. ERK*@Cytosol map
  2. p38*|​T180_pho|​Y182_pho@Cytosol map
  3. DYRK1A@Cytosol map
  4. CDK1:​CyclinB1*@Cytosol map


References
PMID:12792650
Direct phosphorylation of CASP9 by ERK2 sufficient to block CASP9 processing
in vitro, recombinant hCASP9 phosphorylated on T125 by cytosolic extract or ERK2
in Hela cells, interaction GST-CASP9 / ERK
in Hela or HEK293, CASP9 T125 phosphorylation by OA, consititutively active MEK1, EGF or TPA
PMID:17466630
CASP9 T125 phosphorylation by CCNB1:CDC2
comment: phosphorylation during mitosis, when nuclear envelope is broken down
PMID:19081073
CASP9 T125 phosphorylation by DYRK1A
PMID:19016842
PMID:19586613
CASP9 T125 phosphorylation by DYRK1A and p38