Simple molecule Heparin map
Heparin@Extracellular space

Identifiers
Heparin
Enoxaparin
Bemiparin
CAS:N/A PUBCHEM:3664, CHEBI:28304, KEGGCOMPOUND:C00374

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

Heparin@TUMOR_CELL_AS_INDUCTOR_Membrane

References
 NATURAL_KILLER  map
CASCADE:NKP44
CASCADE:NKP30
PMID:23414611, PMID:19196184, PMID:15294952
Heparin is ligand of NKp30, NKp44 and Nkp46. The NCRs initiate tumor targeting by recognition of??heparan??sulfate??on cancer cells.??Tumor cells expressing cell surface heparanase or lacking membranal heparan manifest reduced recognition by NKp30 and NKp46 and are lysed to a lesser extent by NK cells.
in_re159( Innate Immunity  map ):
PMID:11062502, PMID:15536084
ERK1/2 activation induces perforin and granzyme B movement towards target tumor cells downstream of PI3K signaling in NK cells.

Heparin@INNATE_IMMUNE_CELL_Cytosol

References
 MAST_CELL  map
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization,

Modifications:
In compartment: Extracellular space
  1. Heparin@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Heparin@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. Heparin@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
In compartment: Cytosol
  1. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. FGFR family*@Cytosol map + FGF family*@Extracellular space map + Heparin@Extracellular space map → map FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map
  2. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR2|​hm2|​active@Cytosol map
  3. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR1|​hm2|​active@Cytosol map
  4. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR3|​hm2|​active@Cytosol map
  5. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR4|​hm2|​active@Cytosol map
  6. Heparin@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
As Catalyser:
  1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  3. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane map