Protein FGFR3 map

Identifiers
fibroblast growth factor receptor 3
ACH "achondroplasia thanatophoric dwarfism"
HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910

FGFR3|​hm2|​active@Cytosol

References
em_emtc_emtc_re1272( EMT Senescence  map ):
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:12767520
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation

Modifications:
In compartment: Cytosol
  1. FGFR3@Cytosol map
  2. FGFR3|​hm2|​active@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FGFR family*@Cytosol map → map FGFR3@Cytosol map
    2. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR3|​hm2|​active@Cytosol map
    As Catalyser:
    1. SHC1_p66_p52*@Cytosol map → map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map
    2. PLC_gamma_*@Cytosol map → map PLC_gamma_*|​pho|​active@Cytosol map
    3. FRS2@Cytosol map → map FRS2|​pho|​active@Cytosol map